蒙药草乌花中的三酯型二萜生物碱的分离和鉴定

草乌花为乌头属植物北草乌（ＡｃｏｎｉｔｕｍｋｕｓｎｅｚｏｆｆｉｉＲｅｉｃｈｂ）的干燥花序，是常用的蒙药，不需炮制，有杀“粘”、清热、解毒之功效［１］，其活性成分的化学研究未见报道。为探讨蒙医用药的原理，综合利用药用植物资源，寻找高效低毒的有效成分，作者对蒙药草乌花中的活性成分进行了化学研究。本文报道，自苯提取物中分离到７个二萜生物碱，经光谱分析和与已知物相比较，分别鉴定为ｈｙｐａｃｏｎｉｔｉｎｅ（Ｉ），３ａｃｅｔｙｌａｃｏｎｉｔｉｎｅ（ＩＩ），３ａｃｅｔｙｌｍｅｓａｃｏｎｉｔｉｎｅ（ＩＩＩ…

ISOLATION AND IDENTIFICATION OF TRIESTER DIDERPENOID FROM THE FLOWERS OF ACONITUM KUSNEZOFFII REICHB

AIM: To look for new principles of high activity and low toxicity from the flowers of Aconitum kusnezoffii Reichb. METHODS: Various chramatographic techniques were used to separate and purify the constituents. Their physical and chemical properties and spectral data were measured for structure elucidation. RESULTS: Seven compounds were isolated from the benzene extract of the flowers of Aconitum kusnezoffii Reichb, a medicinal plant of Ranunculaceae family. On the basis of spectral data (IR, MS, ¹HNMR ,¹³CNMR and DEPT) and comparisons with known compounds, their structures were identified as hypaconitine (I), 3-acetylaconitine (II), 3-acetylmesaconitine (III), 3-acetylaconifine (IV), mesaconitine (V), beiwutine (VI) and lepenine (VII). CONCLUSION: Compounds III and IV were new natural products. Compounds II～IV showed analgesic and antiinflammatory activities.