从基因组学研究证候实质的若干思考

人类基因组学后基因组时代研究的方法学内容与中医学的整体观、辨证观有很多相似之处，目前已有不少学者在基因水平上对证的实质研究作了有益探索。由于证侯与基因表达差异及基因多态性之间存在着密切的内在联系，所以我们可以此为切入点，充分利用先进的试验方法和检测手段，在基因多态性与证候易感性的相关性研究基础上，深入研究证型的基因差异表达谱，并从功能基因组学的角度对相关基因的调控网络进行分析，进一步研究探讨证候的实质。

Some Thoughts on Studying Essence of Syndromes Based on Genomics

In the postgenomic era, the contents of methodology of human genomics researching is similar to the views of holism and syndromes differentiation of traditional Chinese medicine. So far, many scholars have probed beneficially into the essence of syndrome on the gene level. Since the syndrome of TCM have close intrinsic relations with not only the difference of gene expression but also the gene polymorphisms, therefore, it is capable, taking this as a cut-in point, to clarify the essential of syndrome by fully applying the advanced experimental methods and detecting techniques to deeply investigatc the gene difference expression spectra based on the study of the relationship between gene polymorphisms and syndrome susceptibility, and analyze the regulatory network of the related genes from the view of functional genomics.