心肌缺血预适应对急性心肌梗死病人的影响

目的 对首次急性心肌梗死（ＡＭＩ）发生前２４ｈ、２４￣４８ｈ、大于４８ｈ有无发作过心绞痛的病人的临床状况及近期预后进行评价。方法 １５８例ＡＭＩ病人 分为缺血预适应组４６例，其中２４ｈ内发生心绞痛１１例，２４￣４８ｈ内发生心绞痛６例，大于４８ｈ发生心绞痛２９例；非预适应组１１２例；两组基本临床情况相似。结果 心肌皑 血预适应相比非缺血预适应组心肌梗死范围小（Ｐ〈０．０１），血浆ＣＰＫ、ＬＤＨ、ＡＳ

Effects of ischemic preconditioning on short-termprognosis of acute myocardial infarction

Objective To evaluate the clinical results of the first acute myocedial infarction (ANT) with angina in24 hours, 23~ 28 hours, and over 48 hours before AMI accure and not. Methods 158 cases of the first AMI were devidedinto two groups: ischemia preconditioning (P) group (n = 46) with angina in 24 hours, 24 ~ 28 houxs and over 48 hours be-fore AMI onset, no ischemia preconditioning (NIP) group (n = 112) withou angina. The basic clinical characteristics of thetwo groups were similar. Results The infarction size was smaller in the IP group than those in the NIP group (P < 0.01),the peak value of CPK, LDH and were lower in the IP than tha in the NIP group (P < 0.01), The incidenCes of heartfailure, cardiolgenic shock and cediolgenic mortality during hospitalization were the lower in IP group than those in the NIPgroup (P < 0.05), Therefore, one with angina over 48 hours before AMI was similar with NIP group in clinical results (P >0.05). The incidence of arrhythmia was also similar (P > 0.05) Conclusion The angina withen 48 hours before the firstAMI onset have dafinit cedoprofective effect, these effects are related to the ischemia preconditioning.