Uniparental inheritance of the mitochondrial gene cytochrome b in Plasmodium falciparum |
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| Authors: | Alison M. Creasey Lisa C. Ranford-Cartwright Daphne J. Moore Donald H. Williamson Robert J. M. Wilson David Walliker Richard Carter |
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| Affiliation: | (1) Institute of Cell Animal and Population Biology, University of Edinburgh, West Mains Road, EH9 3JN Edinburgh, Scotland, UK;(2) Parasitology Division, National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, England, UK |
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| Abstract: | The inheritance of an extrachromosomal 6-kb element has been examined in the human malaria parasite Plasmodium falciparum. A single base pair difference in the cytochrome b gene from the 6-kb element of two different cloned lines of the parasite was identified, and used as a marker in a cross in the mosquito stage of the life cycle. Analysis of 59 individual hybrid oocysts resulting from this cross clearly demonstrated that inheritance of the cytochrome b gene was uniparental. This observation makes it possible to investigate the inheritance and evolution of cytoplasmic traits, including certain forms of drug resistance, in natural populations of this parasite. |
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| Keywords: | Plasmodium falciparum Cytochrome b Uniparental inheritance Mitochondrial |
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