| 荷肝癌小鼠的99Tcm-HL91乏氧显像的实验研究 |
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| 引用本文： | 朱广文,张延军,解敬慧,杜雪梅,刘岩岩,陶 莉.荷肝癌小鼠的99Tcm-HL91乏氧显像的实验研究[J].大连医科大学学报,2006,28(6):433-435. |
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| 作者姓名： | 朱广文 张延军 解敬慧 杜雪梅 刘岩岩 陶 莉 |
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| 作者单位： | 大连医科大学,第一临床学院,核医学科,辽宁,大连,116011 |
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| 摘 要： | 目的] 探讨99Tcm-HL91(4,9-二氮-3,3,10,10-四甲基十二烷-2,11-二酮二肟)在荷肝癌H22的高淋巴道转移亚系(Hca-F)瘤细胞的BALB/c小鼠中的显像价值.方法] 用1110MBq/2mL的99TcmO4淋洗液溶解HL91(1 mg),另用10 mL生理盐水溶解1 mg DTPA后,迅速取出50 μL注入上述HL91瓶中,室温下放置10 min后,标记率＞95%. 13只荷肝癌BALB/c小鼠麻醉后,经尾静脉注射37 MBq 99Tcm-HL91后,2 h 3只、4 h 5只、6 h 5只行SPECT平面显像,利用感兴趣区技术(ROI),分别计算不同时相的靶与非靶T/NT(肿瘤与头部、肿瘤与对侧、肿瘤与腹部)的比值. 结果] 99Tcm-HL91在各时相所有荷瘤小鼠的肿瘤均有摄取.注射后4 h放射性最高,随时间推移,6 h略有下降,其放射性下降较其他组织缓慢.HL91在肿瘤乏氧区域高于除腹部外的其他组织.注射后4 h肿瘤/头部、肿瘤/对侧和肿瘤/腹部的比值分别为4.26±2.29、3.40±0.91和0.41±0.19.肿瘤/头部和肿瘤/对侧比值在4、6 h均高于2 h(P＜0.01).随时间推移,T/NT逐渐增高.99Tcm-HL91在肝、肾中滞留最多.结论] 99Tcm-HL91在荷肝癌BALB/c小鼠的肿瘤中摄取良好、清除缓慢.99Tcm-HL91注射后4 h进行显像可以得到较理想的T/NT比值.乏氧显像中T/NT比值是一个非常重要的指标.
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| 关 键 词： | 肝癌 小鼠 放射性核素显像 锝 细胞低氧 |
| 文章编号： | 1671-7295（2006）06-0433-03 |
| 收稿时间： | 2006-06-22 |
| 修稿时间： | 2006-07-14 |
An experimental study on mice bearing liver cancer imaging with 99Tcm-HL91 |
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| ZHU Guang-wen,ZHANG Yan-jun,XIE Jing-hui,DU Xue-mei,LIU Yan-yan and TAO Li.An experimental study on mice bearing liver cancer imaging with 99Tcm-HL91[J].Journal of Dalian Medical University,2006,28(6):433-435. |
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| Authors: | ZHU Guang-wen ZHANG Yan-jun XIE Jing-hui DU Xue-mei LIU Yan-yan and TAO Li |
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| Institution: | Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China |
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| Abstract: | |
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| Keywords: | HL91 |
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