| 高能冲击波治疗膀胱肿瘤的实验研究 |
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| 引用本文： | 张忠林,杨建军,周性明.高能冲击波治疗膀胱肿瘤的实验研究[J].现代医学,1994(3). |
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| 作者姓名： | 张忠林 杨建军 周性明 |
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| 作者单位： | 南京铁道医学院附院泌尿外科 |
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| 摘 要： | 用高能冲击波治疗由Ｎ－甲基亚硝基脲诱导的大鼠膀胱肿瘤的实验研究，病理和电镜观察显示单次高能冲击波对膀胱肿瘤细胞无影响，连续两次高能冲击波处理后，４８小时起出现肿瘤细胞坏死，随时间延长，肿瘤坏死增加。高能冲击波主要引起肿瘤细胞内线粒体肿胀等改变，从而导致细胞坏死，流式细胞仪检查示高能冲击波必理后Ｓ期细胞数明显下降。结果表明连续两次高能冲击波处理对膀胱肿瘤细胞确实存在直接和间接毒性作用。
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| 关 键 词： | 短波治疗，膀胱肿瘤，肿瘤，实验性，流动血细胞计数 |
Experimental Studies on the Treatment ofBladder Tumors lnduced by N-Methyl-Nitrosourea
with High Energy Shock Wave. |
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| Zhang Zhong-lin,et al..Experimental Studies on the Treatment ofBladder Tumors lnduced by N-Methyl-Nitrosourea
with High Energy Shock Wave.[J].Modern Medical JOurnal,1994(3). |
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| Authors: | Zhang Zhong-lin |
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| Abstract: | xperimental studies on thetreatment of ratbladder
tumors induced by N-methyl-N-ni-trosourea(MNU)with high energy shockwave(HESW)were
performed.The resultsof the histological and ultrastructural observa-tions showed that one
exposure of HESW hadno influences on the bladder tumor cells.2days of serial exposures
could induce necrosisfrom 48 hours on. As tirme going, degress oftumor necrosis gradually
increased. HESWcaused some changes in mitochondria after ex-posuers and resulted in
eventual cell death.Flow cytometric analysis showed that the cellsin S phase in bldder tumors
significantly de-creased. It was concluded that 2 days of serialexposures were cytotoxic to
bladder tumorsinduced MNU. |
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| Keywords: | short-wave therapybladder tumor flow cytometric analysisneoplasms experimental |
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