Disorders of pyruvate carboxylase and the pyruvate dehydrogenase complex |
| |
Authors: | B. H. Robinson N. MacKay K. Chun M. Ling |
| |
Affiliation: | (1) Departments of Biochemistry and Paediatrics, University of Toronto, M5G 1X8 Toronto, Ontario, Canada;(2) Department of Genetics, The Research Institute, The Hospital for Sick Children, 555 University Avenue, M5G 1X8 Toronto, Ontario, Canada |
| |
Abstract: | Summary The most common defect associated with deficiency of the pyruvate dehydrogenase (PDH) complex occurs in the E1 component, specifically due to mutations in the X-linked E1 gene. Clinical sequelae of these mutations, which range from severe neonatal lactic acidosis to carbohydrate-sensitive ataxia, can be different in males and females depending on the nature of the mutation and, in the case of females, on the X-inactivation pattern in different tissues. Males have a high representation of missense mutations among the patient cohort, while females are much more likely to have DNA rearrangements, particularly toward the 3 end of the coding sequence of the gene. Missplicing mutations involving exon 6 deletion have been reported, as has a missense mutation conferring true thiamin-responsiveness of the enzyme and the patient's clinical symptoms.Pyruvate carboxylase deficiency, on the other hand, is a true autosomal recessive disease, though it has high occurrences in particular ethnic groups, especially in Algonkian-speaking Amerindians and in Arabs. In the former group the defect is a simple type in which material cross-reactive to pyruvate carboxylase antibody is present in cultured cells (CRM+ve). In the latter group, cross-reacting material is rarely present (CRM–ve). The CRM+ve patients can survive into teenage years with careful supervision, while the CRM–ve patients have complications due to hyperammonaemia and dysfunction of the urea cycle and rarely survive beyond 3 months of life. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|