急性缺血性脑卒中炎性指标与循环内皮祖细胞的关系

目的:探讨急性缺血性脑卒中患者血浆白介素-6(IL-6)、超敏C反应蛋白(hsCRP)水平与循环内皮祖细胞(EPCs)的关系.方法:选择2008年9月至2010年6月在我科经头颅CT证实诊断的急性缺血性脑卒中患者56例为研究组,以同期门诊健康体检者30例为对照组.检测两组就诊时IL-6、hsCRP及循环EPCs水平.结果:研究组血浆IL-6、hsCRP及循环EPCs水平均明显高于对照组,P ＜ 0.05;研究组患者IL-6、hsCRP与循环EPCs存在正相关,其相关系数分别为(r ＝ 0.367,P ＝ 0.030)及(r ＝ 0.429,P ＝ 0.016).结论:在急性缺血性脑卒中患者中,在炎症损伤反应水平升高的同时,循环EPCs可能作为一种保护机制,其水平亦相应升高.

Correlation between Endothelial Progenitor Cells and Inflammatory Factors in Patients with Acute Ischemic Stroke

Objective： To investigate the relationship between endothelial progenitor cells and inflammatory factors （IL-6 and hsCRP） in patients with acute isehemic stroke. Methods： 56 patients with acute ischemic stroke diagnosed by computer tomography as research group and 30 health persons as control group were observed from Sep. 2008 to Jun.2010. The levels of IL-6, hsCRP and circulating EPCs were examined in the both group. Results： The levels of IL-6, hsCRP and circulating EPCs were significantly increased in research group than those in the control group,P〈0.05. There were positive correlation between IL-6, hsCRP and circulating EPCs, the correlation coefficient were r=0.367（P=0.030） and r= 0.429（P=0.016） respectively. Conclusion： Circulating EPCs might be an auto-protect mechanism in patients with acute ischemic stroke. The levels of circulating EPCs significantly increased as well as the levels of IL-6 and hsCRP.