深圳市龙岗区中学生乙型肝炎流行状况及防治对策

目的了解深圳市龙岗区中学生乙型肝炎病毒感染状况及影响因素,为制定有效的干预措施提供依据。方法采用酶联免疫吸附试验（ELISA法）检测HBV血清标志物（HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc）和谷丙转氨酶（ALT）。结果共检测的1250名中学生,HBsAg阳性者66人,阳性率为5.28%;初中学生HBsAg的阳性率低于高中学生,差异有统计学意义（P〈0.05）;男生的感染率高于女生,差异有统计学意义（P〈0.05）;在HBsAg阳性的学生中,HBV-DNA阳性率为53.03%,HBeAg阳性率为60.61%。结论HBV感染与家族乙肝病史、输血及血制品的使用有关。中学生HBsAg阳性群体处于乙肝病毒复制活跃期,有较强的传染性。

Survey of prevalant status of hepatitis B in middle school students of Longgang District and control measures

Objective To understand infectious status of HBV in middle school students and the risk factors. Methods Fasting venous blood （5ml）was collected from middle school studends, HBV markers i.e. HBsAg, anti -HBs, anti -HBe, anti -HBc and glutamic pyruvic transaminase （ALT）were detected by ELISA method. Results There 84 students were positive for HBsAg with a positive rate of 5.28%, The positive rate in junior middle school studems was a little lower than the senior students, showing significantly statistical difference （ P 〈 0.05）, The infection rate in males was higher than that of the females, also showing siguificantly statistical difference. The positive rates for HBV - DNA and HBeAg were 53.03% and 60. 61% respectively among the students positive for HBsAg, Conclusion HBV infection is associated with famifial history of hepatitis B, blood transfusion and use of blood products.