912和AK-2123对辐射荷瘤小鼠的内分泌效应

昆明小鼠移植S_(180)肉瘤后5天,行肿瘤局部X线照射,单次剂量5Gy,连续5天,照前40min腹腔注射 912(和AK—2123)。结果显示,于照射后7天,注射912小鼠血清皮质酮水平即开始降低,照后17天降低最为明显;而血清睾丸酮水平和睾丸cAMP含量趋于升高。另外,912与AK—2123联合应用时,与单独给予912的变化一致。提示,912具有抑制皮质酮分泌和某种程度的促进睾丸cAMP产生和睾丸酮分泌的作用,其作用机理可能与神经内分泌—免疫网络调节有关;而AK—2123(或者与912联合应用时)对内分泌系统功能作用不明显。

Effect of 912 and AK-2123 on endocrine of tumor-bearing mice radiated by X-rays

Kunmin mice were used implanted with S110 sarcoma cells. Five days after implantation, the tumor was radiated with X - rays in a fractional dose of 5. 0 Gy for 5 days continuously, and 912 (and AK 2123) were injected 40 min before irradiation. It was found that serum CS level in the mice injected with 912 started to lower 7 days after irradiation, and became lowered very obviously 17 days after irradiation, while serum TS level and testicular cAMP content tended to rise. In addition, when 912 was used together with AK -2123, the effect remained the same. These results suggest that 912 can inhibit CS secretion and promote testicular cAMP production and TS secretion to some extent, and its effective mechanism may be related to neuroendocrine-immune network regulation, while the effect of AK-2123 (or in combination with 912) on endocrine is not obvious.