| 大黄素治疗高脂饮食诱发的大鼠非酒精性脂肪肝的实验研究 |
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| 引用本文： | 董慧,陆付耳,高志强,徐丽君,王开富,邹欣. 大黄素治疗高脂饮食诱发的大鼠非酒精性脂肪肝的实验研究[J]. 中国中西医结合杂志, 2006, 0(Z1) |
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| 作者姓名： | 董慧 陆付耳 高志强 徐丽君 王开富 邹欣 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院中西医结合研究所 华中科技大学同济医学院附属同济医院中西医结合研究所 武汉 |
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| 基金项目： | 湖北省重点攻关项目(No．2002AA302B13) |
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| 摘 要： | 目的探讨大黄素对高脂饮食诱发的大鼠非酒精性脂肪肝的治疗作用。方法高脂饮食饲养12周诱导SD大鼠非酒精性脂肪肝模型,肝脏病理切片证实造模成功,造模大鼠4|D只随机分为5组,大黄素(低、中、高剂量)组给予相应剂量的大黄素灌胃,每日1次,饮食治疗组及模型对照组灌服蒸馏水,除模型组外,其余各组均进食普通饮食。4周后分别检测各组的肝指数、肝功能、血脂、肝脂及肝组织学改变。结果模型对照组体重、肝指数、肝酶活性、血脂、肝脂显著升高(P＜0．05,P＜0．01),高密度脂蛋白胆固醇明显降低(P＜0．01),肝脏呈中、重度脂肪变；与模型对照组比较,不同剂量大黄素治疗能显著降低血脂、肝脂,改善肝功能(P＜0．05,P＜0．01)；而饮食治疗仅使肝组织学有改善,但血清谷丙转氨酶、血清甘油三酯和胆固醇增高持续存在。结论大黄素合并饮食治疗高脂饮食诱发的大鼠非酒精性脂肪肝有效。
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| 关 键 词： | 大黄素 非酒精性脂肪肝 |
Experimental Study on Effects of Emodin on Nonalcoholic Fatty Liver Induced by High Fat Diet in Rats |
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| DONG hui LU Fu-er GAO Zhi-qiang Institute of Integrated Chinese and Western Medcine,Tongji Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan. Experimental Study on Effects of Emodin on Nonalcoholic Fatty Liver Induced by High Fat Diet in Rats[J]. Chinese journal of integrated traditional and Western medicine, 2006, 0(Z1) |
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| Authors: | DONG hui LU Fu-er GAO Zhi-qiang Institute of Integrated Chinese Western Medcine Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science Technology Wuhan |
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| Abstract: | Objective To investigate the therapeutic effect of emodin on nonalcoholic fatty liver(NAFL)in- duced by high fat diet in rats.Methods NAFL model was established by feeding with high fat diet for 12 weeks in 40 SD rats,confirmed by liver pathologic examination,which were randomly divided into 5 groups:the model control group the mere dietary treatment group(both with distilled water by gastrgarege),the low,moderate and high dose emodin groups treated with emodin 20,40 and 80 mg·kg~(-1)·d~(-1)once per day res... |
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| Keywords: | emodin nonalcoholic fatty liver |
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