| 着色性干皮病基因D多态性与慢性苯中毒发病风险 |
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| 引用本文： | 李岩,张忠彬,孙品,万俊香,金锡鹏,夏昭林.着色性干皮病基因D多态性与慢性苯中毒发病风险[J].卫生研究,2010,39(3). |
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| 作者姓名： | 李岩 张忠彬 孙品 万俊香 金锡鹏 夏昭林 |
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| 作者单位： | 1. 山东省职业卫生与职业病防治研究院,济南,250062
2. 复旦大学公共卫生学院 |
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| 基金项目： | 国家自然科学基金资助项目(No.30271113); 国家973项目(No.2002CB512902) |
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| 摘 要： | 目的探讨XPD的基因多态性与个体慢性苯中毒发病风险的关系。方法采用病例-对照设计,以152名苯中毒工人为病例组,152名接触苯而没有中毒表现的工人为对照组。应用聚合酶链反应-限制性片断长度多态性分析技术(PCR-RFLP)检测XPDc.199、XPDc.201、XPDc.312和XPDc.751位点的多态性。结果未检测到XPDc.199、XPDc.201位点的突变基因型;与携带XPDc.312Asp/Asp基因型的个体相比,调整性别、工龄和暴露强度后,携带XPDc.312Asp/Asn+Asn/Asn基因型的个体的慢性苯中毒的发病风险降低(ORadj=0.59,95%CI=0.35～0.99,χ2=3.99,P0.05),在低强度苯接触组,该突变基因型的保护作用更为显著(ORadj=0.15,95%CI=0.04～0.51,χ2=8.93,P0.01)。结论XPDAsp312Asn基因多态可能与个体慢性苯中毒发病风险的改变有关。
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| 关 键 词： | 苯中毒 着色性干皮病基因D 基因多态性 |
Genetic polymorphism in XPD related to risks of chronic benzene poisoning |
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| LI Yan,ZHANG Zhongbin,SUN Pin,WAN Junxiang,JIN Xipeng,XIA Zhaolin.Genetic polymorphism in XPD related to risks of chronic benzene poisoning[J].Journal of Hygiene Research,2010,39(3). |
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| Authors: | LI Yan ZHANG Zhongbin SUN Pin WAN Junxiang JIN Xipeng XIA Zhaolin |
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| Institution: | LI Yan,ZHANG Zhongbin,SUN Pin,WAN Junxiang,JIN Xipeng,XIA Zhaolin Sh,ong Academy of Occupational Health , Occupational Medicine,Jinan 250062,China |
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| Abstract: | Objective To explore the relation between genetic polymorphisms in XPD and risks of chronic benzene poisoning(CBP).Methods A case-control study was conducted.152 CBP patients and 152 NCBP workers occupationally exposed to benzene were investigated.Polymerase chain reaction-restrained fragment length polymorphism technique(PCR-RFLP) was applied to detect the single nucleotide polymorphisms(SNPs) at c.199,c.201,c.312 and c.751 of XPD gene.Results No variant alleles was detected at c.199 and c.201 of XPD gene.... |
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| Keywords: | benzene poisoning xeroderma pigmentosum complementation group D genetic polymorphism |
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