| 阻癌胃泰对胃癌前病变大鼠胃窦部P物质、血管活性肠肽和降钙素基因相关肽的影响 |
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| 引用本文： | 王垂杰,李岩,任明智. 阻癌胃泰对胃癌前病变大鼠胃窦部P物质、血管活性肠肽和降钙素基因相关肽的影响[J]. 中国中西医结合杂志, 2006, 0(Z1) |
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| 作者姓名： | 王垂杰 李岩 任明智 |
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| 作者单位： | [1]辽宁中医学院附属医院 [2]沈阳 |
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| 基金项目： | 辽宁省科委资助项目(No：2001101028) |
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| 摘 要： | 目的探讨胃癌前病变与胃窦部P物质(SP)、血管活性肠肽(VIP)、降钙素基因相关肽(CGRP)的关系及中药制剂阻癌胃泰的治疗机制。方法采用N-甲基-N-硝基-N-亚硝基胍(MNNG)合并胃黏膜机械损伤方法制作了胃癌前病变大鼠模型。选用中药制剂阻癌胃泰进行预防和治疗给药,观察了大鼠模型胃黏膜病理形态变化,同时用免疫组化法检测了SP、VIP、CGRP含量变化。结果胃窦部SP、CGRP的含量中药组比西药组有明显提高(P＜0．05),但VIP含量比较差异无显著性。(P＞0．05)。结论无论是预防给药还是治疗给药,阻癌胃泰能提高大鼠胃窦部SP、VIP、CGRP的含量。
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| 关 键 词： | 胃癌前病变 阻癌胃泰 P物质 血管活性肠肽 降钙素基因相关肽 |
Effect of Zu'ai Weitai Granule on Substance P,Vasoactive Intestinal Peptide,Calcitonin Gene-related Peptide of Precancerous Lesion of Gastric Antrum in Rats |
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| WANG Chui-jie LI Yan Ren Ming-zhi The Affiliated Hospital of Liaoning College of TCM,Shenyang. Effect of Zu'ai Weitai Granule on Substance P,Vasoactive Intestinal Peptide,Calcitonin Gene-related Peptide of Precancerous Lesion of Gastric Antrum in Rats[J]. Chinese journal of integrated traditional and Western medicine, 2006, 0(Z1) |
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| Authors: | WANG Chui-jie LI Yan Ren Ming-zhi The Affiliated Hospital of Liaoning College of TCM Shenyang |
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| Abstract: | Objective To explore the relationship between precancerous lesions of gastric antrum and sub- stance P(SP),vasoactive intestinal peptide(VIP),calcitonin gene-related peptide(CGRP),and the therapeutic mechanism of Zu ai Weitai Granule(ZWG),a TCM preparation.Methods The rat model of precancerous lesions of gastric carcinoma was induced by the combined method of N-methyl N -nitrosoguani-dine(MNNG)and mechani- cal injury on gastric mucosa.The pathologic morphological changes of gastric mucosa were observed afte... |
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| Keywords: | precancerous lesions of gastric carcinoma Zu'ai Weitai Granule substance P vasoactive intestinal peptide calcitonin gene-related peptide |
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