Post-synthetic modification in vivo of the major hemoglobin beta chain in the rat |
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Authors: | L M Garrick M L Chu P Rusnak-Smalley M D Garrick |
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Affiliation: | Department of Biochemistry, State University of New York, Buffalo 14214. |
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Abstract: | Rat hemoglobins are unusually heterogeneous among mammals. This heterogeneity provides multiple opportunities for asynchronies in synthesis and degradation. We have examined rat hemoglobin turnover after an intravenous injection of 2-14C-glycine. After analyzing incorporation into the seven nonallelic globin chains of adult rats, we found the percentage of the major beta chain decreases over the red cell lifespan while the percentage of one of the minor beta chains increases. This suggests that a post-synthetic modification event converts a portion of the latter into the former. |
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