姜黄提取物固体分散体的制备及体外评价

目的 制备共聚维酮-泊洛沙姆姜黄提取物固体分散体PVP/VA-Poloxamer-Curcumae Longae Rhizoma extract (CLRE)solid dispersion (SD),PAP-CSD]、共聚维酮姜黄提取物固体分散体(PVP/VA CLRE solid dispersion,PA-CS...

Preparation and in vitro evaluation of solid dispersion of Curcumae Longae Rhizoma extract

Objective To prepare PVP/VA-Poloxamer-Jianghuang (Curcumae Longae Rhizoma) extract (CLRE) solid dispersion (SD) (PAP-CSD), PVP/VA CLRE solid dispersion (PA-CSD), Poloxamer CLRE solid dispersion (P-CSD), increase the solubility of CLRE in water and the dissolution rate of CLRE in vitro, and improve the stability and hygroscopicity of solid dispersions. Methods For three SDs prepared by solvent method, in vitro evaluation of CLRE, PAP-CSD, PA-CSD and P-CSD were achieved by investigation of in vitro dissolution, hygroscopicity, stability, and phase characterization. Results Three solid dispersion systems: PAP-CSD, PA-CSD and P-CSD were prepared successfully, the CLRE was evenly dispersed in the SD. The results of in vitro evaluation showed that when the ratio of CLRE to carrier was 1:10, the dissolution of the SD was the best. And the dissolution of the mixed carrier was better than that of Poloxamer-188, the hygroscopicity of the mixed carrier was lower than that of the single carrier of PVP/VA. Conclusion PAP-CSD, PA-CSD and P-CSD could improve the solubility and dissolution rate of CLRE, the combination of the two carriers was better than the single carrier.