| 慢性社交挫败应激抑郁模型建立与评价及其在中药抗抑郁研究中的应用 |
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| 引用本文： | 王琦,赵慧亮,杨晨,向欢,秦雪梅,田俊生.慢性社交挫败应激抑郁模型建立与评价及其在中药抗抑郁研究中的应用[J].中草药,2022,53(1):288-294. |
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| 作者姓名： | 王琦 赵慧亮 杨晨 向欢 秦雪梅 田俊生 |
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| 作者单位： | 山西大学中医药现代研究中心, 地产中药功效物质研究与利用山西省重点实验室, 山西大学化学生物学与分子工程教育部重点实验室, 山西太原 030006;山西大学体育学院, 山西太原 030006 |
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| 基金项目： | 国家“重大新药创制”科技重大专项（2017ZX09301047）；国家自然科学基金资助项目（82074147）；山西省科技厅重点研发计划项目（201903D321210）；地产中药功效物质研究与利用山西省重点实验室（202105D121009） |
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| 摘 要： | 慢性社交挫败应激抑郁(chronic social defeat stress depression,CSDS)模型是利用生理和心理双重应激使实验动物出现抑郁样状态,进一步以传统抑郁动物模型评价指标及社会交互作用指数进行评价.该模型可以较好地模拟人类在日常的交往活动中因为社交压力过大、频繁的挫败感或长期遭受欺凌而导致的...
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| 关 键 词： | 社交挫败抑郁疾病 慢性社交挫败应激抑郁模型 社会交互作用指数 心理应激 社会功能 |
| 收稿时间： | 2021/8/9 0:00:00 |
Establishment and evaluation of chronic social defeat stress depression model and its application in study on antidepressant effect of traditional Chinese medicine |
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| WANG Qi,ZHAO Hui-liang,YANG Chen,XIANG Huan,QIN Xue-mei,TIAN Jun-sheng.Establishment and evaluation of chronic social defeat stress depression model and its application in study on antidepressant effect of traditional Chinese medicine[J].Chinese Traditional and Herbal Drugs,2022,53(1):288-294. |
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| Authors: | WANG Qi ZHAO Hui-liang YANG Chen XIANG Huan QIN Xue-mei TIAN Jun-sheng |
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| Institution: | Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China;School of Physical Education, Shanxi University, Taiyuan 030006, China |
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| Abstract: | Chronic social defeat stress depression (CSDS) model is a kind of depression-like state in experimental animals caused by physiological and psychological stress. And it is further evaluated by traditional indexes of depressive state and social interaction ratio. CSDS model can better simulate the depressive behavior caused by excessive social pressure, frequent defeat, or being long-term bullied in human daily communication activities. Meanwhile, the effect of drugs on improvement of depression and social function can also be evaluated in animal-level studies by using this model. In this paper, establishment methods, evaluation indexes, and application of the model in the study on antidepressant effect of traditional Chinese medicine are reviewed, in order to provide important support for the study of pathological mechanism of depression as well as research and mechanism of action of antidepressant drugs. |
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| Keywords: | social defeated depression chronic social defeat stress depression model social interaction index psychological stress social function |
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