| PI3K/AKT通路在肺癌转移和耐药中的研究 |
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| 引用本文： | Zhu B,Zhou X. PI3K/AKT通路在肺癌转移和耐药中的研究[J]. 中国肺癌杂志, 2011, 14(8): 689-694. DOI: 10.3779/j.issn.1009-3419.2011.08.10 |
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| 作者姓名： | Zhu B Zhou X |
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| 作者单位： | 1. 第三军医大学研究生六队,重庆,400038
2. 西南医院呼吸内科,重庆,400038 |
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| 基金项目： | 国家自然科学基金(No.30971308)资助~~ |
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| 摘 要： | 磷脂酰肌醇-3-激酶/丝苏氨酸蛋白激酶(phosphatidyl-inositol 3-kinase/serine-threonine kinase,PI3K/AKT)信号通路是细胞内重要信号转导通路之一,通过影响下游多种效应分子的活化状态,在细胞内发挥抑制凋亡、促进增殖的关键作用,与人类多种肿瘤的发生发展密切相关。研究表明PI3K/AKT信号通路在恶性肿瘤细胞的增殖、血管新生和转移及对放化疗的拮抗中都起着重要作用。对PI3K/AKT信号通路的深入研究有望找到肿瘤预防和药物治疗的新靶点。本文简要介绍了PI3K/AKT信号通路的组成与功能调节,并着重阐述了其在肺癌转移和耐药中的作用。
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| 关 键 词： | PI3K/AKT 信号转导 肿瘤转移 耐药 肺肿瘤 |
The study of PI3K/AKT pathway in lung cancer metastasis and drug resistance |
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| Zhu Bingjing,Zhou Xiangdong. The study of PI3K/AKT pathway in lung cancer metastasis and drug resistance[J]. Chinese journal of lung cancer, 2011, 14(8): 689-694. DOI: 10.3779/j.issn.1009-3419.2011.08.10 |
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| Authors: | Zhu Bingjing Zhou Xiangdong |
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| Affiliation: | Bingjing ZHU1,Xiangdong ZHOU2 1Sixth Graduate Student Group,the Third Military University,Chongqing 400038,China,2Department of Respiratory Medicine,Southwest Hospital |
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| Abstract: | PI3K/AKT signal pathway is an important intracellular signal transduction pathway.It plays important roles in cell apoptosis and survival by affecting the activity of downstream effector molecules,and it is closely associated with the development and progression of human tumors.Recent researches of PI3K/AKT indicate that this pathway plays important roles in tumor cells proliferation,blood vessel neogenesis,tumor metastasis and resistance to chemotherapy and radiotherapy.The profound research of PI3K/AKT is... |
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| Keywords: | PI3K/AKT Signal transduction Tumor metastasis Drug resistance Lung neoplasms |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
