| CYP1A1和GSTM1基因多态性及其对个体肺癌易感性的联合效应:meta分析 |
| |
| 引用本文： | Li C,Yin Z,Zhou B. CYP1A1和GSTM1基因多态性及其对个体肺癌易感性的联合效应:meta分析[J]. 中国肺癌杂志, 2011, 14(8): 660-668 |
| |
| 作者姓名： | Li C Yin Z Zhou B |
| |
| 作者单位： | 中国医科大学公共卫生学院流行病学教研室辽宁省高校肿瘤病因与预防重点实验室循证医学中心; |
| |
| 摘 要： | 背景与目的谷胱甘肽转移酶M1(glutathione S-transferase M1,GSTM1)和细胞色素P4501A1(cyto-chrome P450A1,CYP1A1)均存在基因多态性,并且对肺癌发病风险有一定的影响,两者联合作用对肺癌发病风险的影响尚无确切定论。本研究旨在探讨CYP1A1和GSTM1基因多态性及其联合效应与肺癌危险性的关系。方法在PubMed数据库、EMBASE数据库、中国生物医学文献数据库(china biology medicine,CBM)和中国知识基础设施工程数据库(china national knowledge infrastructure,CNKI)中查询文献,时间范围从各数据库建库至2011年3月。使用STATA10软件进行meta分析统计,对于每篇入选的文献均计算肺癌发生危险性调整混杂因素后优势比(odd ratio,OR)及其95%置信区间(confidence interval,CI)。结果 15篇文献最终被纳入本次研究。Meta分析显示GSTM1基因缺失时CYP1A1基因IIe/Val位点为纯合突变型时肺癌发病风险明显高于杂合型与纯合突变型联合,总体OR分别...
|
| 关 键 词： | CYP1A1 GSTM1 基因多态性 肺肿瘤 meta分析 |
CYP1A1 gene and GSTM1 gene polymorphism and the combined effects and risk of lung cancer: a meta-analysis |
| |
| Li Cheng,Yin Zhihua,Zhou Baosen. CYP1A1 gene and GSTM1 gene polymorphism and the combined effects and risk of lung cancer: a meta-analysis[J]. Chinese journal of lung cancer, 2011, 14(8): 660-668 |
| |
| Authors: | Li Cheng Yin Zhihua Zhou Baosen |
| |
| Affiliation: | Cheng LI,Zhihua YIN,Baosen ZHOU Department of Epidemiology,School of Public Health,China Medical University,The Key Laboratory of Cancer Control in Liaoning Province,China Medical University Center for Evidence Based Medicine,Shenyang 110001,China |
| |
| Abstract: | Background and objective Cytochrome P450A1(CYP1A1) gene and glutathione S-transferase M1(GSTM1) gene both have single nucleotide polymorphisms and effects on lung cancer.Currently,however,the risk of lung cancer due to the CYP1A1 and GSTM1 genes has no clear evidence.In this present study,we propose to research the combined effects of CYP1A1 gene and GSTM1 gene polymorphism and their risks to lung cancer.Methods We conducted the study at different research areas and using various database,including PubMed,E... |
| |
| Keywords: | Cytochrome P450A1(CYP1A1) Glutathione S-transferase M1(GSTM1) Genetic polymorphism Lung neoplasms meta-analysis |
| 本文献已被 CNKI PubMed 等数据库收录！ |
|
