精氨酸、左旋多巴单日复合与两日序贯激发生长激素分泌的效果评价

[目的]比较矮小儿童精氨酸与左旋多巴单日复合与两日序贯两种方式激发生长激素(growth hormone,GH)分泌的试验效果.[方法]将77例矮小症儿童随机分为两组,单日复合组(复合组)39例,精氨酸、左旋多巴清晨一次同时给予,复合进行GH激发;两日序贯组(序贯组)38例,精氨酸、左旋多巴分两天,序贯进行GH激发,以...

Effects of two growth hormone provocative tests(arginine and levodopa combined or sequential ways)among children with short stature

【Objective】 To compare the effects of two growth hormone(GH) provocative tests(arginine and levodopa combined or sequential ways) among children with short stature. 【Methods】 77 children with short stature were divided into 2 groups randomly.The combined group(39 cases) was given with arginine and levodopa at the same time to stimulate GH secretion,while the sequential group(38 cases) was given with arginine and levodopa separately in two days.The peak value of GH and the positive incidence of the two stimulation tests were compared.Peak value <10 ng/mL was defined as negative test and peak value >10 ng/mL was defined as positive test. 【Results】 The GH peak value in combined group and sequential group were(15.55±7.50) ng/mL and(13.80±9.23) ng/mL respectively.The incidence of positive test in combined group(82.0%) was significantly higher than sequential group(60.5%). 【Conclusion】 The GH provocative test performed in combined way has a higher positive incidence than in sequential way,and is more reliable in diagnosing GH deficiency.