Mismatch of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and Tc-99m pertechnetate single photon emission computed tomography (SPECT) in a euthyroid multinodular goiter |
| |
Authors: | Goethals Ingeborg Mervillie Kris De Winter Oliver Delrue Louke Mekeirele Katia Ham Hamphrey |
| |
Institution: | Department of Nuclear Medicine, Ghent University Hospital, Gent. ingeborg.goethals@ugent.be |
| |
Abstract: | Imaging results of F-18 fluorodeoxyglucose (FDG) PET/CT scanning and Tc-99m pertechnetate scintigraphy of the thyroid gland are described and compared with pathology in a patient who was followed after left nephrectomy for renal cell carcinoma diagnosed 10 years earlier. On F-18 FDG PET/CT scanning, a multinodular struma with increased localized F-18 FDG uptake in 4 nodules was seen. Two nodules with increased glucose metabolism appeared normal on Tc-99m pertechnetate scintigraphy. Pathology indicated hyperplastic nodules. High focal F-18 FDG uptake was also seen in a lesion that corresponded with a "cold" nodule on Tc-99m pertechnetate scintigraphy, suggesting malignant disease. However, pathology revealed hyperplastic nodules with a background of aspecific lymphocytic thyroiditis. A fourth nodule with increased F-18 FDG uptake appeared mixed ("cold"/"hot") on Tc-99m pertechnetate scintigraphy. On pathology, a well-differentiated follicular carcinoma was found. These findings, in a single patient, illustrate the wide spectrum of matched and mismatched F-18 FDG and Tc-99m pertechnetate thyroid uptake along with their variable pathologic correlates. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|