肾移植患者全血他克莫司浓度监测结果分析

目的：探讨肾移植患者全血他克莫司浓度的治疗窗及对血常规和肝肾功能的影响。方法：MEIA法监测全血他克莫司谷浓度。对近4年来390例次肾移植患者全血他克莫司浓度，及他克莫司对血常规和肝肾功能的影响进行分析。结果：390例次全血他克莫司浓度中377例次（80．8％）在3～15μg·L^-1的范围内。移植后6个月内，全血他克莫司浓度差异较大。随着移植时间延长，全血他克莫司浓度逐步降低。在治疗剂量内，他克莫司对肾移植受者的血常规和肝肾功能无明显影响。结论：全血他克莫司谷浓度的治疗窗：术后1～3月为5～15·L^-1，第4～6月为5～10·L^-1，〉6个月为3～10·L^-1。他克莫司对肾移植受者的血常规和肝肾功能无明显影响。

Analysis of Blood Tacrolimus Concentrations in Renal Transplant Recipients

Objective ： To investigate the therapeutic range of tacrolimus and effects of tacrolimus on liver and renal functions and blood routine in renal transplant recipients. Method： The whole blood tacrolimus concentration was measured by micro-particle enzyme immunoassay （MEIA）. Blood tacrolimus concentrations in 390 cases of renal transplant recipients were analyzed. The effects of tacrolimus on liver and renal function and blood routine were also studied. Result： The blood tacrolimus concentrations in 377 of 390 cases were within the range from 3 to 15 μg·L^-1. Their blood tacrolimus concentration differed greatly in renal transplant recipients within 6 months after transplantation. Their blood tacrolimus concentration was gradually decreased as time went on. Tacrolimus with therapeutic dosage had no effects on liver and renal function and blood routine. Conclusion： The therapeutic ranges of tacrolimus with MEIA were as follows： 5 to 15 μg·L^-1within 3 months after transplantation, 5 to 10 μg·L^-1 between 4 to 6 months after transplantation ,3 to 10μg·L^-1 6 months after transplantation, The administration of tacrolimus had no effects on the liver and renal function and blood routine in renal transplant recipients.