A new model of the depressive syndrome induced by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in rats |
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| Authors: | G. N. Kryzhanovskii N. A. Krupina V. G. Kucheryanu |
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| Affiliation: | (1) Laboratory of General Pathology of the Nervous System, Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Animals treated with MPTP neurotoxin displayed lowered motor and exploratory activity in the open field test, reduced daily intake of water with a preference for sugar solution over water, prolonged immobilization, and increased index of depression in the forced swimming test. The changes in rat behavior were preserved for at least a week after withdrawal of the drug. The data attest to the development of a state of lowered motivational activity combined with ahedony and “behavioral despair” in response to MPTP, making it possible to consider this state as a new experimental model of dopamine-dependent depressive syndrome in rats. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N o 2, pp. 125–128, February, 1995 |
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| Keywords: | MPTP rats depressive syndrome model |
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