18例罕见胚胎发育不良性神经上皮肿瘤的治疗

目的探讨胚胎发育不良性神经上皮肿瘤（dysembryoplastic neuroepithelial tumor，DNT）的临床治疗特点。方法对2001年至2007年治疗18例DNT病人的临床症状，影像学、电生理和病理资料进行回顾性分析。结果18例DNT病人表现癫痫发作，发作形式与部位有关，14例行脑电图描记，其中10例行术中皮层脑电图描记切除病灶，术后随访1月～6年，3例仍有癫痫发作，15例癫痫发作消失，无肿瘤复发。结论DNT属良性肿瘤，手术效果良好，行术中脑电图描记可有效切除癫痫灶。

Surgical treatment of dysembryoplastic neuroepithelial tumor

Objective To explore the clinical features and managements of dysembryoplastic neuroepithelial tumor(DNT).Methods The clinical manifestations,radiological appearances,electrophysiological characteristics and pathological findings of 18 DNT cases from 2001 to 2007 were retrospectively analyzed.Results All patients exhibited episodes of epilepsy,with various types associated with the location of the lesion.Out of 18 cases,the epileptogenic lesions in 14 patients were identified by electroencephalography(EEG) prior to the operation and 10 were further localized by EEG in operation.All lesions were surgically removed and all patients were followed up from 1 month to 6 years.The epilepsy seizure relapsed in 3 patients and the others were seizure free after the operation.The tumor did not relapse in any patients during the follow-up.Conclusions Surgical resection is an ideal treatment for DNT and the epileptogenic lesions could be identified by EEG in operation.