| 不同介质对甲壳胺-替加氟缓释作用的影响 |
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| 引用本文： | 王艳萍,吕新强,何保安.不同介质对甲壳胺-替加氟缓释作用的影响[J].医药论坛杂志,2005,26(13):30-33. |
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| 作者姓名： | 王艳萍 吕新强 何保安 |
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| 作者单位： | 河南省胸科医院药剂科,郑州市,450008;河南省胸科医院药剂科,郑州市,450008;河南省胸科医院药剂科,郑州市,450008 |
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| 摘 要： | 目的研究甲壳胺-替加氟缓释片在不同介质中的释放性质。方法以甲壳胺为辅料，采用湿颗粒法制备甲壳胺-替加氟缓释片，分别以盐酸溶液(0．1mol／L)、磷酸盐缓冲液(pH6．8)、蒸馏水为介质采用转篮法测定其释药情况，并与市售替加氟片作对比．结果甲壳胺-替加氟缓释片在0．1mol／L盐酸溶液中可持续释放达12h以上，而在蒸馏水及磷酸盐缓冲液中1h已释放达90％以上。结论甲壳胺-替加氟缓释片的缓释作用对介质pH值的依赖性较强。
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| 关 键 词： | 甲壳胺-替加氟缓释片 甲壳胺 缓释作用 |
| 文章编号： | 1672-3422(2005)13-0030-04 |
| 修稿时间： | 2005年4月14日 |
Investigation of Effect of Different Solvents on Sustained- release Action of Chitosan - tegafur Sustained - release Tablets |
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| WANG Yanping,LU Xinqiang,HE Baoan.Investigation of Effect of Different Solvents on Sustained- release Action of Chitosan - tegafur Sustained - release Tablets[J].Journal of Medical Forum,2005,26(13):30-33. |
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| Authors: | WANG Yanping LU Xinqiang HE Baoan |
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| Institution: | WANG Yanping,LU Xinqiang,HE Baoan Pharmacy Department of Henan Chest Hospital,Zhengzhou 450008,China |
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| Abstract: | Objective To study the release characteristics of chitosan-tegafur sustained-release tablets in different solvents. Methods Sustained tablets were prepared by direct compressing with an excipient of chitosan,and the release characteristics of the tablets were evaluated in 0.1 mol/L HCL;solution of phosphate(pH6.8); distilled water and compared with market tegafur tablets.Results The sustained-tablets could maintain release of tegafur in 0.1 mol/L HCL above 12h;but the release characteristics in distilled water and solution of phosphate are 90% in 1h. Conclusion The sustained action of chitosan-tegafur depends on the pH value of the solvents. |
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| Keywords: | Chitosan-tegafur sustained-release tablets Chitosan Sustained action |
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