Anatomical differentiation within the nucleus accumbens of the locomotor stimulatory actions of selective dopamine agonists andd-amphetamine |
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Authors: | William D. Essman Paul McGonigle Irwin Lucki |
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Affiliation: | (1) Department of Psychiatry, University of Pennsylvania, 3600 Market St., 19104-2649 Philadelphia, PA, USA;(2) Department of Pharmacology, University of Pennsylvania Medical School, 19104-6084 Philadelphia, PA, USA |
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Abstract: | The effects of local injections of dopamine receptor agonists into various areas within the nucleus accumbens or the medial caudate-putamen on the generation of locomotor activity were examined. Combinations of 0.32 µg/side of the dopamine receptor agonists SKF 38393 (D1) and quinpirole (D2) produced increases in locomotor activity that varied according to the rostral-caudal placement of the cannulae within the nucleus accumbens. The greatest levels of locomotion were generated by injections into a region in the caudal-central nucleus accumbens, with lower levels of activity elicited by injections into more rostral or caudal regions. A similar pattern of responses was produced by administration of the indirect dopamine agonistd-amphetamine. These results indicate that there is marked heterogeneity in the response of discrete sub-regions of the nucleus accumbens to dopamine receptor stimulation and that this heterogeneity is functionally expressed in the mediation of the locomotor effects of dopaminergic agonists. |
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Keywords: | Dopamine SKF 38393 Quinpirole d-Amphetamine Nucleus accumbens Localization Locomotor activity Rat |
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