| 不同透皮吸收促进剂对玄丹巴布剂体外透皮吸收作用的影响 |
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| 引用本文： | 孟舒,刘铁兵,隋新,关艳敏. 不同透皮吸收促进剂对玄丹巴布剂体外透皮吸收作用的影响[J]. 中国药师, 2010, 13(1): 9-10 |
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| 作者姓名： | 孟舒 刘铁兵 隋新 关艳敏 |
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| 作者单位： | 1. 辽宁省计划生育科研院,沈阳,110031
2. 苏家屯妇婴医院 |
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| 基金项目： | 辽宁省科技厅科技攻关项目 |
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| 摘 要： | 目的：探讨不同的透皮吸收促进剂对玄丹巴布剂中淫羊藿苷体外透皮吸收作用的影响，筛选出有效的透皮吸收促进剂，以提高玄丹巴布剂的疗效。方法：采用正交试验法，以淫羊藿苷的透过率为评价指标考察了氮酮、丙二醇、薄荷脑3个因素对玄丹巴布剂透皮吸收影响。结果：薄荷脑用量为2％，氮酮用量为3％时，淫羊藿苷透皮吸收率最高，促透效果最明显，而丙二醇对淫羊藿苷透皮率影响较小。结论：氮酮、薄荷脑可提高玄丹巴布剂淫羊藿苷体外透皮吸收量。
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| 关 键 词： | 玄丹巴布剂 透皮吸收促进剂 淫羊藿苷 |
Transdermal Absorption Effect of the Different Penetrate Enhancers on the Icarrine in the Xuan-dan Cataplasm in Vitro |
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| Meng Shu,Liu Tiebing,Sui Xin,Guan Yanmin. Transdermal Absorption Effect of the Different Penetrate Enhancers on the Icarrine in the Xuan-dan Cataplasm in Vitro[J]. China Pharmacist, 2010, 13(1): 9-10 |
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| Authors: | Meng Shu Liu Tiebing Sui Xin Guan Yanmin |
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| Affiliation: | Meng Shu~1,Liu Tiebing~2,Sui Xin~2,Guan Yanmin~1(1.Liaoning Institute of Family Planning,Shenyang 110031,China,2.Sujiatun Woman and Baby Hospital) |
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| Abstract: | Objective:To discuss the transdermal absorption effect of the different penetrate enhancers on the icarrine in the Xuandan cataplasm in vitro to select the effective penetrate enhancers,meanwhile,improve the curative efficacy of this cataplasm.Method: The orthogonal design was adopted with three factors as menthol,azone and propanediol.The penetrate rates of icarrine were tested as evaluation index.Result:The optimum condition of transdermal effect was used 2%menthol and 3%Azone as penetrate enhancers,but t... |
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| Keywords: | Xuan-dan cataplasm Penetrate enhancer Icarrine |
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