肿瘤时辰治疗的研究与探索

大量研究表明抗肿瘤化疗药物具有昼夜节律性。按照时辰药理学原理进行肿瘤时辰治疗，对于减少不良反应，增加最大耐受量，提高疗效方面的优越性，已为现代临床研究证实。现综述各类时辰化疗药物的特性，阐明药物化疗的疗效与毒性和昼夜节律有关，同时说明放疗也存在着时辰依赖性。开展肿瘤时辰治疗正日益受到重视。

Research and exploration in tumor circadian therapy

Scientists have found tumor growth is timing of the gene activity in tumor cells is at least partly highly dependent on time of day, and that the off killer. Due to the circadian rhythm in cancer, tumor cells are more vulnerable to anticancer drugs at certain points in their circadian cycle. According to principles of circadian-rhythm cancer, clinical studies suggested that the chronotherapy against tumor growth appears more advantages in reduction of adverse reactions, increase of maximal tolerance and response to chemotherapy. The importance of tumor chronotherapy has gained prominence. This paper highlights characteristics of variety of circadian chemotherapeutics, and relationship of the circadian rhythms with therapeutic effects and toxicities of chemotherapeutics. The circadian rhythm of radiotherapy in the time-dependent manner is also discussed.