Genetic and dietary influences on urinary oxalate excretion |
| |
Authors: | Ross P Holmes Dean G Assimos Harold O Goodman |
| |
Institution: | (1) Department of Urology, Bowman Gray School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA; Tel: +1 (910) 716-4231, fax: +1(910) 716-0174, e-mail: rholmes@bgsm.edu, US |
| |
Abstract: | Several genes contribute to the development of calcium oxalate nephrolithiasis as it is a polygenic disease. To explore the
influence of genetic factors on oxalate excretion we have examined the distribution of oxalate excretions in 101 normal individuals
who consumed self-selected diets. The distribution was apparently trimodal, consistent with the existence of three classes
of oxalate excretors reflecting two allelic genes determining high and low oxalate excretion occurring with frequencies of
0.32 and 0.68 respectively. The pattern of inheritance in eight families was compatible with the expression of a pair of codominant
alleles. A comparison of the distribution of excretory classes among the 101 normal individuals with that of 101 calcium oxalate
stone formers suggests that high oxalate excretion may be associated with a 4-fold increased risk of stone disease and intermediate
excretion with a 1.6-fold increase. Control of dietary factors influencing oxalate excretion apparently improved the discrimination
between excretory classes in 17 individuals but the intra-individual variability in oxalate excretion was not reduced in four
of nine individuals in whom this parameter was evaluated. More stringent dietary control than that applied in this study may
be required before more extensive genotyping of individuals is attempted.
Received: 4 February 1997 / Accepted: 22 October 1997 |
| |
Keywords: | Oxalate Dictary oxalate Genetic effects Urinary excretions Urolithiasis Kidney stones |
本文献已被 SpringerLink 等数据库收录! |