| 天然抗肝细胞毒活性化合物2R 3R（＋）水飞蓟宾的全合成 |
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| 引用本文： | 李绍顺 计志忠. 天然抗肝细胞毒活性化合物2R 3R（＋）水飞蓟宾的全合成[J]. 中国药物化学杂志, 1997, 7(2): 107-111 |
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| 作者姓名： | 李绍顺 计志忠 |
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| 作者单位： | [1]第二军医大学基础部 [2]沈阳药科大学药物研究所 |
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| 摘 要： | 提拱了２Ｒ３Ｒ（＋）水飞蓟宾全合成的新方法，以取代的查尔酮为原料，经不对称环氧化，手性ＨＰＬＣ柱分离，立体选择性环合得光学纯的２Ｒ３Ｒ（＋）黄杉素，然后，与松柏醇经立体选择性氧化缩合得２Ｒ３Ｒ（＋）水习蓟宾。
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| 关 键 词： | 水飞蓟宾 中药 全合成 |
Total Synthesis of 2R 3R ( ) Silybin as an Antihepatoxic Natural Product |
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| Li Shaoshun,Wu Yueping. Total Synthesis of 2R 3R ( ) Silybin as an Antihepatoxic Natural Product[J]. Chinese Journal of Medicinal Chemistry, 1997, 7(2): 107-111 |
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| Authors: | Li Shaoshun Wu Yueping |
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| Abstract: | This paper provides a new method of total synthesis of 2R 3R ( ) silybin. Optically pure(100?) 2R 3R ( ) silybin was prepared from oxidative coupled coniferyl alcohol with 2R 3R ( ) taxifolin which was synthesized by asymmetric epoxidation of chalcone and HPLC chiroptical resolution,then stereoselective cyclization. |
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| Keywords: | R 3R ( ) silybin total synthesis 2R 3R ( ) taxifolin stereoselective synthesis |
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