Cytotoxic constituents ofSorbaria sorbifolia var.stellipila |
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| Authors: | Dae Keun Kim Sang Hoon Choi Jung Ock Lee Shi Yong Ryu Dae Kyu Park Dae Hee Shin Jee Hyung Jung Suhk Keung Pyo Kang Ro Lee Ok Pyo Zee |
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| Affiliation: | (1) College of Pharmacy, Sung Kyun Kwan University, 440-746 Suwon, Korea;(2) Korea Research Institute of Chemical Technology, 136-702 Daejeon, Korea;(3) Chosun Pharm. & Trading Co. Institute of Life Science Research, 1229 Ansan, Korea;(4) College of Pharmacy, Pusan University, 609-735 Pusan, Korea |
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| Abstract: | The acivity-guided fractionation upon the MeOH extract of the aerial parts ofSorbaria sorbifolia var.stellipila led to the isolation of two cucurbitacin-compounds, cucurbitacin D and cucurbitacin F, as active principles. Two compounds were shown to exhibit significant cytotoxicity against cultured human tumor cell lines, A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT 15. |
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| Keywords: | Sorbaria sorbifolia var.stellipila Cucurbitacin D Cucurbitacin F Cytotoxicity |
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