激素联合来氟米特治疗狼疮性肾炎疗效观察

目的了解来氟米特（LEF）治疗Ⅳ型狼疮性。肾炎的临床效果、安全性和副作用。方法59例狼疮性肾炎（LN）患者，肾活检显示为狼疮性肾炎，应用来氟米特联合糖皮质激素治疗6个月。用药期间监测血常规、尿常规、24h尿蛋白定量、肝肾功能、抗核抗体及抗双链抗体滴度、红细胞沉降率和补体c3等，6个月后行疗效和安全性的评价。结果来氟米特治疗LN尿蛋白缓解率为72．4％，高于环磷酰胺冲击治疗缓解率（57％），LN活动性指标缓解率也高于后者。结论来氟米特联合糖皮质激素治疗能有效控制狼疮活动且副作用轻，耐受性好。

Leflunomide combined hormone treating the lupus nephritis

Objective leflunomide (LEF) treatment of lupus nephritis Ⅳ clinical results,safety and side effects.Methods 59 patients with lupus nephritis (LN) patients,renal biopsy showed lupus nephritis as the application of leflunomide combined with glucocorticoids for 6 months.During the monitoring of medication blood,urine,24 h urinary protein,liver and kidney function,antinuclear antibody and anti-double stranded antibodies titer,erythrocyte sedimentation rate,C3,etc.,6 month after assessment of the efficacy and safety.Results of leflunomide treatment of LN remission urine protein was 72.4% ,higher than the remission rate cyclophosphamide pulse therapy (57%),LN activity index remission rate than the latter.Conclusion leflunomide therapy combined with glucocorticoids to control disease activity and side effects of light and well tolerated.