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| 具有磁感应定向加热治疗肿瘤作用的锰锌铁氧体纳米粒子的制备及其特性检测 | |
| 引用本文： | 樊祥山,张东生,郑杰,顾宁,丁安伟,贾秀鹏,秦洪云,金立强,万美玲,李群慧. 具有磁感应定向加热治疗肿瘤作用的锰锌铁氧体纳米粒子的制备及其特性检测[J]. 生物医学工程学杂志, 2006, 23(4): 809-813 |
| 作者姓名： | 樊祥山 张东生 郑杰 顾宁 丁安伟 贾秀鹏 秦洪云 金立强 万美玲 李群慧 |
| 作者单位： | 1. 东南大学,基础医学院,病理学与病理生理学系、分子病理研究所,南京,210009 2. 东南大学,生物医学工程系,南京,210096 3. 南京中医药大学,药学院,南京,210029 4. 东南大学,附属中大医院,南京,210009 |
| 基金项目： | 国家自然科学基金;江苏省自然科学基金;江苏省中医药、中西医结合重点项目;东南大学校科研和教改项目 |
| 摘 要： | 采用改良的化学共沉淀法制备Mn0.5Zn0.5Fe2O4纳米磁性材料，用透射电镜、分析仪及热分析系统等进行表征及特性检测。将Mn0.5Zn0.5Fe2O4纳米粒子以及其不同浓度的磁流体置于200KHz的交变磁场中照射，检测其磁感应自控加热作用；用Mn0.5Zn0.5；Fe2O4浸渍液体外干预小鼠L929成纤维细胞，通过检测细胞增值率来评价其细胞毒性。结果表明，制备的锰锌铁氧体纳米粒子为圆形，约40nm，并经检索X-线粉末衍射图库证实；纳米锰锌铁氧体磁流体能磁感应加热而升温到40℃～51℃，且最终温度能稳定控制不变；纳米锰锌铁氧体浸渍液对细胞未见明显毒性作用。 |
| 关 键 词： | 锰锌铁氧体 纳米材料 磁感应加热 靶向治疗 |
| 修稿时间： | 2004-07-21 |
Preparation and Characterization of Nano-magnetoparticles with Radiofrequency-induced Hyperthermia for Cancer Treatment |
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| Fan Xiangshan,Zhang Dongsheng,Zheng Jie,Gu Ning,Ding Anwei,Jia Xiupeng,Qing Hongyun,Jin Liqiang,Wan Meiling,Li Qunhui. Preparation and Characterization of Nano-magnetoparticles with Radiofrequency-induced Hyperthermia for Cancer Treatment[J]. Journal of biomedical engineering, 2006, 23(4): 809-813 | |
| Authors: | Fan Xiangshan Zhang Dongsheng Zheng Jie Gu Ning Ding Anwei Jia Xiupeng Qing Hongyun Jin Liqiang Wan Meiling Li Qunhui |
| Affiliation: | Department of Pathology and Pathophysiology, Institute of Molecular Pathology, Medical School Southeast University, Nanjing 210009,China;Department of Biomedical Engineering, Southeast University, Nanjing 210096 ,China;College of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing 210029 ,China;Affiliated Zhongda Hospital, Southeast University, Nanjing 210009,China |
| Abstract: | Mn0.5Zn0.5Fe2O4 nano-particles were prepared by the chemical co-precipitation, their characteristics were observed with transmission electron microscope (TEM), X-ray diffractometer (XRD) and thermal analysis system, and etc. The temperature changes of the nano-particles of Mn0.5Zn0.5Fe2O4 and its magnetic fluid explored in radiofrequency(RF,200 KHz, 4 KW) were measured. The proliferation ratio of L929 cells cultured in soak of Mn0.5Zn0.5Fe2O4 nano-particles were observed. The experiment indicates that the magnetic particles were about 40 nm diameter in average, round, had strong magnetism, and were proved to be consistent with the standard data of chart of XRD. Its magnetic fluid exposed to RF could be heated up to temperature range from 40 degrees C to 51 degrees C due to the amount of the magnetic nano-particles and intensity of the alternating magnetic field. Magnetic nano-particles were found to have no obvious cytotoxicity to L929 cells. |
| Keywords: | Mn-Zn ferrite Nano-particles Radiofrequency-induced hyperthermia Targeted therapy |
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