Protonation equilibrium and lipophilicity of moxifloxacin |
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Authors: | Langlois Marie-Hélène Montagut Martine Dubost Jean-Pierre Grellet Jean Saux Marie-Claude |
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Institution: | Laboratory of Analytical Chemistry, EA 2962, Bordeaux Il University, Bordeaux, France. |
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Abstract: | This study was performed to characterise the protonation equilibrium at the molecular level and pH-dependent lipophilicity of moxifloxacin. After determining macro- and micro-constants, distribution features of four microspecies in aqueous phase were assessed. The apparent partition coefficient versus pH profile of moxifloxacin showed a parabolic curve in n-octanol/buffer system which reached near pI. The true partition coefficient was calculated from the log P(app) and microconstants values. |
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