| 食管癌高发区人胎儿食管上皮的透射电镜观察 |
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| 引用本文： | 邢国兰,郭军辉,王立东,聂春红,范宗民. 食管癌高发区人胎儿食管上皮的透射电镜观察[J]. 重庆医学, 2007, 36(5): 439-440,443 |
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| 作者姓名： | 邢国兰 郭军辉 王立东 聂春红 范宗民 |
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| 作者单位： | 郑州大学医学实验中心癌症研究室,河南省食管癌重点开放实验室,郑州,450052;郑州大学第一附属医院肾病内科,450052;郑州大学第一附属医院肾病内科,450052;郑州大学医学实验中心癌症研究室,河南省食管癌重点开放实验室,郑州,450052;河南省辉县市计划生育服务中心,453600 |
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| 基金项目： | 国家自然科学基金 , 河南省高校杰出科研创新人才工程项目 |
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| 摘 要： | 目的 了解食管癌高发区人胎儿食管上皮的超微结构改变.方法 电镜和光镜观察.结果 13周胎儿的食管上皮为复层扁平上皮,有3～5层细胞.细胞结构较清晰细胞间连接以中间连接为主,较少缝隙连接.24～28周时上皮增至4～10层, 细胞结构清晰,细胞间连接以缝隙连接为主,较少中间连接.结论 13～28周胎儿食管上皮中,细胞连接缝隙连接渐占优势,可能为食管癌高发区胎儿食管上皮发育超微结构特点之一.
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| 关 键 词： | 食管癌高发区 食管上皮 超微结构 人胚胎 细胞连接 |
| 文章编号： | 1671-8348（2007）05-439-03 |
| 修稿时间： | 2006-11-06 |
Observation of human fetal esophageal epithelium with transmission electron microscope in high incidence area for esophageal cancer |
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| XING Guo-lan ,QIN Ken ,WANG Li-dong ,et al.. Observation of human fetal esophageal epithelium with transmission electron microscope in high incidence area for esophageal cancer[J]. Chongqing Medical Journal, 2007, 36(5): 439-440,443 |
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| Authors: | XING Guo-lan QIN Ken WANG Li-dong et al. |
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| Affiliation: | 1. Laboratory for Cancer, Experimental Center for Medicine, Zhengzhou University ; Henan Key Laboratory for Esophageal Cancer ; Department of Medicine,First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052;2. Department of Nephrology ,First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China ; 3. Service Center for Birth Control, Huixian, Huixian Henan , 453600, China |
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| Abstract: | Objective To find out the ultrastructure change of human fetal esophageal epithelium in the high incidence area of esophageal cancer. Methods The changes were observed by electron microscope and light microscope. Results At 13 weeks, the morphologic structure of fetal esophageal epithelium was stratified squamous epithelium with 3-5 cell layers. The cellularity was relatively clear. The majority of cell junction was intermediate junction and with less gap junction. During 24- 28 weeks, the epithelial layer increased to 4-10 layers, the cellularity was clear, with more gap junction and less intermediate junction. Conclusion gap junction held predominance gradually in human fetal esophageal epithelium from 13 to 28 weeks. Maybe it is one of the ultrastructure characters in the evolution of human fetal esophageal epithelium. |
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| Keywords: | high incidence area of esophageal cancer esophageal epithelium ultrastruct ure human embryo cell junction |
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