Exploring epistatic relationships of NO biosynthesis pathway genes in susceptibility to CHD |
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| Authors: | Yuan-chao TU Hu DING Xiao-jing WANG Yu-jun XU Lan ZHANG Cong-xin HUANG Dao-wen WANG |
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| Institution: | [1]Department of Cardiology, Renmin Hospital of Wuhan University; [2]Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; [3]Center for Craniofacial and Dental Genetics School of Dental Medicine, University of Pittsburgh, PA 15219, USA |
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| Abstract: | Aim:To assess the epistatic relationships of nitric oxide (NO) biosynthesis pathway genes in susceptibility to coronary heart disease (CHD).Methods:A total of 2142 subjects enrolled in two case-control studies was genotyped for 7 single-nucleotide polymorphisms (SNP) within NO biosynthesis pathway genes using TaqMan assays. The association analyses were performed at both SNP and haplotype levels. Two-way SNP-SNP interactions and high-order interactions were tested using multiple unconditional logistic regression analyses and generalized multifactor dimensionality reduction (GMDR) analyses, respectively.Results:Two alleles (rs1049255*C and rs841*A) were identified that were significantly associated with increased risk of CHD after adjusting for all confounders (OR=1.21, 95% CI: 1.06−1.39, combined P=0.001, Pcorr=0.007 and OR=1.30, 95% CI 1.12−1.50, combined P<0.001, Pcorr<0.001, respectively). Significant two-way SNP–SNP interactions were found between SNP rs2297518 and these two significant polymorphisms, affecting the risk of CHD (P<0.001 for both). No significant high-order interactions were identified.Conclusion:The results suggested that two-way SNP–SNP interactions of polymorphisms within NO biosynthesis pathway genes contribute to CHD risk. |
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| Keywords: | coronary heart disease nitric oxide genetics epitasis interaction single-nucleotide polymorphism case control study |
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