| 衡阳地区初诊2型糖尿病患者谷氨酸脱羧酶抗体筛查 |
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| 引用本文： | 王建平,李晶,邓珊珊,孙蓉,呙劲松,郑薇,董晨珊,黄干,周智广. 衡阳地区初诊2型糖尿病患者谷氨酸脱羧酶抗体筛查[J]. 南华大学学报(医学版), 2011, 39(2): 170-172 |
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| 作者姓名： | 王建平 李晶 邓珊珊 孙蓉 呙劲松 郑薇 董晨珊 黄干 周智广 |
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| 作者单位： | 1. 南华大学第二附属医院,内分泌科,湖南,衡阳,421001
2. 中南大学湘雅二医院,代谢内分泌研究所 |
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| 摘 要： | 目的探讨衡阳地区初诊2型糖尿病（T2DM）患者中成人隐匿性自身免疫性糖尿病（LADA）的患病率及其临床特征。方法对102例病程1年以内非酮症起病的初诊T2DM患者采用放射配体法检测谷氨酸脱羧酶抗体（GADA）,同时测量身高、体重、体质指数（BMI）、血压,检测空腹血糖、空腹C肽（FCP）、糖化血红蛋白（HbA1c）、血脂、超敏促甲状腺激素（uTSH）、甲状腺球蛋白抗体（TG-Ab）与甲状腺过氧化物酶抗体（TPOAb）,比较GADA阳性患者与GADA阴性患者之间的临床特征与生化特征差异。结果初诊T2DM患者GADA阳性率即LADA患病率为9.8%（10/102）;与GADA阴性患者比较,GADA阳性LADA患者BMI较小,空腹C肽水平较低,uTSH异常检出率与TPOAb阳性率增高（均P〈0.05）。结论衡阳地区初诊2型糖尿病患者中存在一定比例的LADA患者;对于BMI较小、胰岛功能较差的初发T2DM患者应及早检测GADA。
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| 关 键 词： | 2型糖尿病 成人隐匿性自身免疫性糖尿病 谷氨酸脱羧酶抗体 |
| 收稿时间： | 2010-10-15 |
Screening of GADA in Newly Diagnosed Type 2 Diabetic Patients in Hengyang Area |
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| WANG Jian-ping,LI Jing,DENG Shan-shan,et al. Screening of GADA in Newly Diagnosed Type 2 Diabetic Patients in Hengyang Area[J]. Journal of Nanhua University(Medical Edition), 2011, 39(2): 170-172 |
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| Authors: | WANG Jian-ping LI Jing DENG Shan-shan et al |
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| Affiliation: | WANG Jian-ping,LI Jing,DENG Shan-shan,et al(Department of Endocrinology,Second Hospital Affiliated to University of South China,Hengyang,Hunan 421001,China) |
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| Abstract: | Objective To investigate prevalence and clinical feature in newly diagnosed type 2 diabetic(T2DM) patients in Hengyang area.Methods 102 newly diagnosed type 2 diabetic patients whose course of disease within one year and without ketosis were measured glutaminic acid decarboxylase antibodies(GADA)by radioligand binding assay.At the same time,Ht,Wt,BMI,BP,FBG,FCP,HbA1c,TG,TC,HDLC,LDLC,uTSH,TG-Ab and TPO-Ab were measured,and the clinical and biochemistry difference between the GADA positive patients and GADA n... |
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| Keywords: | T2DM LADA GADA |
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