| 醋酸氯己定栓剂的制备及质量控制 |
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| 引用本文： | 唐健. 醋酸氯己定栓剂的制备及质量控制[J]. 南华大学学报(医学版), 2011, 39(2): 227-229 |
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| 作者姓名： | 唐健 |
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| 作者单位： | 南华大学附属南华医院,药剂科,湖南,衡阳421002 |
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| 摘 要： | 目的制备醋酸氯己定栓剂并建立其质量控制方法。方法以甘油和明胶为辅料,醋酸氯己定为主要成分制备栓剂,采用紫外分光光度法测定醋酸氯己定的含量。结果醋酸氯己定在2~10μg/mL浓度范围内线性关系良好（r=0.999 6）,平均回收率为99.6%,RSD=0.85%（n=9）。结论酸氯己定栓剂制备工艺可行,含量测定方法简便、准确可靠。
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| 关 键 词： | 醋酸氯己定 制备 质量控制 |
| 收稿时间： | 2010-09-27 |
Preparetion and Quality Control of Chlorhexidine Acetate Suppository |
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| TANG Jian. Preparetion and Quality Control of Chlorhexidine Acetate Suppository[J]. Journal of Nanhua University(Medical Edition), 2011, 39(2): 227-229 |
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| Authors: | TANG Jian |
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| Affiliation: | TANG Jian(The Affiliated Nanhua Hospital of University of South China,Hengyang,Hunan 421002,China) |
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| Abstract: | Objective To prepare chlorhexidine acetate suppository and establish a method for quality control.Method Gelatin and glycerin were used as the vehicle,Chlorhexidine acetate suppository as main ingredient.The UV-spectrophotometry was used for quantitative analysis.Result The calibration curve of chlorhexidine acetate suppository was linear within a range of 2～10 μg/mL（r=0.999 6）,the average recovery of chlorhexidine acetate suppository was 99.6%,RSD=0.86%（n=9）.Conculsion The chlorhexidine acetate suppository is feasible in technological process.The method of content determination is simple and accurate. |
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| Keywords: | chlorhexidine acetate preparetion quality control |
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