| 外源性胰岛素对2型糖尿病患者血小板功能的影响 |
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| 引用本文： | 肖淳纯,任安,叶山东,杨静,李素梅,邢学农.外源性胰岛素对2型糖尿病患者血小板功能的影响[J].中国临床保健杂志,2011,14(3):246-248. |
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| 作者姓名： | 肖淳纯 任安 叶山东 杨静 李素梅 邢学农 |
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| 作者单位： | 安徽医科大学附属省立医院、安徽省立医院内分泌科,合肥,230001 |
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| 摘 要： | 目的观察外源性胰岛素对2型糖尿病患者血小板功能的影响。方法初诊2型糖尿病患者(R组)20例,检测其FBG以及反映血小板活化状态的各个指标,包括血小板膜上GMP-140、PAC-1的表达率,ADP诱导的血小板的聚集率,然后行胰岛素强化治疗,两周后复测上述各指标。另设健康对照组(N组)20例。结果基线时,R组FBG、ADP诱导的血小板聚集率、血小板GMP-140、PAC-1的表达率均明显高于N组,差异有统计学意义(P<0.01);治疗2周后,R组FBG、ADP诱导的血小板聚集率、血小板GMP-140、PAC-1的表达率均明显低于基线时,差异有统计学意义(P<0.01);治疗2周后,R组上述指标仍明显高于N组(P<0.01)。结论短期胰岛素强化治疗可降低初诊2型糖尿病患者体内增强的血小板功能。
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| 关 键 词： | 糖尿病 2型 胰岛素 血小板聚集 |
The influence of exogenous insulin therapy on the function platelet function in type-2 diabetics |
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| XIAO Chun-chun,REN An,YE Shan-dong,YANG Jing,LI Su-mei,XING Xue-nong.The influence of exogenous insulin therapy on the function platelet function in type-2 diabetics[J].Chinese JOurnal of Clinical Healthcare,2011,14(3):246-248. |
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| Authors: | XIAO Chun-chun REN An YE Shan-dong YANG Jing LI Su-mei XING Xue-nong |
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| Institution: | XIAO Chun-chun,REN An,YE Shan-dong,YANG Jing,LI Su-mei,XING Xue-nong(Department of Endocrinology,Anhui Provincial Hospital,Hefei 230001,China) |
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| Abstract: | Objective To observe the influence of exogenous insulin on the platelet function of type 2 diabeticpatients.Methods 20 newly diagnosed type 2 diabetic patients(Group R) were gived intensified insulin treatment for two weeks.At the beginning,Fasting blood glucose(FBG),platelet activation indexes such as the expression ratio of GMP-140,PAC-1 on the platelet membrane and the packing fraction of the platelets derived by ADP were measured in all the subjects.Two weeks later,the variables above mentioned in Group... |
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| Keywords: | Diabetes mellitus type 2 Insulin Platelet aggregation |
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