Role of non-adrenergic non-cholinergic inhibitory nerves in the colon of patients with ulcerative colitis |
| |
Authors: | Ryouichi Tomita Keimei Munakata Katsuhisa Tanjoh |
| |
Institution: | (1) First Department of Surgery, Nihon University School of Medicine, 30-1 Ohyaguchi Kamimachi, Itabashi-ku, Tokyo 173, Japan, JP |
| |
Abstract: | The cause of impaired colonic motility in patients with ulcerative colitis (UC) is unknown. The non-adrenergic non-cholinergic
(NANC) inhibitory nervous system is one of the most important factors in the enteric nervous system of human gut. To assess
the physiological significance of NANC inhibitory nerves in the colon of patients with UC, we investigated the enteric nerve
responses of colonic tissues from patients with this disease. Colonic tissues were obtained from the lesional sigmoid colons
of six patients with UC. Normal sigmoid colonic tissues obtained from ten patients with colonic cancer were used as controls.
A mechanographic technique was used to evaluate in-vitro muscle responses to the electrical field stimulation (EFS) of adrenergic
and cholinergic nerves before and after treatment with various autonomic nerve blockers. NANC inhibitory nerves were found
to act on both normal colon and the lesional colon of patients with UC, but colon with UC was more strongly innervated by
NANC inhibitory nerves than was the normal colon. These findings suggest that NANC inhibitory nerves play an important role
in the impaired motility observed in the colon of patients with UC.
Received Feb. 3, 1997; accepted May 23, 1997 |
| |
Keywords: | : ulcerative colitis non-adrenergic non-cholinergic inhibitory nerves motility mechanographic |
本文献已被 SpringerLink 等数据库收录! |
|