老年肺心病患者下呼吸道分离的鲍曼不动杆菌耐药性动态观察

目的 监测分离自老年肺心病患者下呼吸道的鲍曼不动杆菌的耐药性，探讨其变化规律，为临床治疗提供依据。方法 对2000—2002年下呼吸道标本所分离的革兰阴性杆菌使用VITEK-JR全自动细菌鉴定仪鉴定菌种，并用GNS-KI及GNS-112药敏卡测定鲍曼不动杆菌对12种抗菌药物的体外耐药情况。结果 亚胺培南耐药率为3．8％、5．8％、7．7％；呋喃妥因耐药率为100％；其他抗菌药物耐药率多呈上升趋势。结论 鲍曼不动杆菌多种抗菌药物耐药性迅速上升，应加强老年肺心病患者对该菌耐药性的监测。合理谨慎使用抗生索是延缓耐药菌株快速上升的最好办法。

Dynamic observation of the drug resistance in Acinetobacter isolated from lower respiratory tract in elderly cor pulmonale

Objective To monitor the drug resistance in Acinetobacter isolated from lower respiratory tract in elderly cor pulmonale and investigate its changing tendency. Methods Gram negative bacilli: separated from the samples of lower respiratory tract were identified with VITEK JR auto bacterium evaluation instrument. A.baumanii resistances to 12 kinds of antibacterial drugs were measured in vitro by GNS KI and GNS 112 drug sensitive cards. Results The rate of imipenem resistance in Acinetobacter was 3 8%,5 8%and 7 7%; the rate of berkfuran resistance in Acinetobacter was 100%; a tendency towards increasing resistance of A.baumanii to the other antibiotics were also revealed. Conclusion Acinetobacter resistance to many antibiotics is increasing quickly,and monitoring its antibiotic resistance should be intensified. The correct use of antibiotics is the best way to decrease the drug resistance.