Allergens in urban schools and homes of children with asthma |
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| Authors: | Permaul Perdita Hoffman Elaine Fu Chunxia Sheehan William Baxi Sachin Gaffin Jonathan Lane Jeffrey Bailey Ann King Eva Chapman Martin Gold Diane Phipatanakul Wanda |
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| Institution: | Division of Pediatric Pulmonary, Allergy and Immunology, Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA Division of Respiratory Epidemiology, Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA Division of Immunology, Department of Medicine, Children's Hospital, Boston, MA, USA Division of Pulmonary and Respiratory Diseases, Department of Medicine, Children's Hospital, Boston, MA, USA School Facilities Management, Boston, MA, USA Indoor Biotechnologies Inc, Charlottesville, VA, USA. |
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| Abstract: | To cite this article: Permaul P, Hoffman E, Fu C, Sheehan W, Baxi S, Gaffin J, Lane J, Bailey A, King E, Chapman M, Gold D, Phipatanakul W. Allergens in urban schools and homes of children with asthma. Pediatr Allergy Immunol 2012: 23: 543-549. ABSTRACT: Background: Most studies of indoor allergens have focused on the home environment. However, schools may be an important site of allergen exposure for children with asthma. We compared school allergen exposure to home exposure in a cohort of children with asthma. Correlations between settled dust and airborne allergen levels in classrooms were examined. Methods: Settled dust and airborne samples from 12 inner-city schools were analyzed for indoor allergens using multiplex array technology (MARIA). School samples were linked to students with asthma enrolled in the School Inner-City Asthma Study (SICAS). Settled dust samples from students' bedrooms were analyzed similarly. Results: From schools, 229 settled dust and 197 airborne samples were obtained. From homes, 118 settled dust samples were obtained. Linear mixed regression models of log-transformed variables showed significantly higher settled dust levels of mouse, cat and dog allergens in schools than homes (545% higher for Mus m 1, estimated absolute difference 0.55?μg/g, p?
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