| Abstract: | From 1981 through 1983, we performed three
allogeneic bone marrow transplants for the treatment
of leukemia. They were the first three cases ofsustained bone marrow engraftment in China. The
sustained engraftment was proven by cytogenetic,
isozyme, and blood group analyses. The patients are
all well at the time of writing this report.The first patient was a 19-year-old female with
acute monocytic leukemia. After she had attained
complete remission, she was treated with a protocol
including intravenous cyclophosphamide (1.8 g/m2/
day X 2) and total body irradiation (TBI) of 600 rads
followed by a bone marrow transplant from her bro
ther. MTX and daily intravenous placental v-glo-
bulin were administered after narrow infusion.
Although moderate acute and chronic graft versus
host disease (GVHD) did occur, they were controlled
by treatment. The second patient was a 12-year-old
boy with early relapse of acute granulocytic leukemia.
He received essentially the same protocol as the first
patient. Acute and chronic GVHD, as well as septi-
.cemia, occurred after transplanatation but were con
trolled. The third patient was an adult woman with
chronic granulocytic leukemia in the chronic phase.
.She received essentially the same protocol except that
the TBI was 700 rads and much less MTX was given.
Her pht chromosome disappeared gradually after
bone marrow transplantation. She had mild acute
and chronic GVHD, which were controlled.
Cytogenetic analysis provided evidence of a graft
versus leukemia effect. We hold that intravenous
.placental Y.globulin in large dosages, which had not
previously been used in BMT recipients, might help
to control GVHD by exerting an immunosuppres.
sive effect through a feedback mechanism. |
