miRNA在冠心病治疗中的作用及与中医药的相关性

miRNA是一条19~23核苷酸的非编码RNA,在生物的生长,分化,细胞增殖,凋亡中起到了重要的作用。冠心病常常伴随病理性重塑反应,损伤心脏的收缩力,其中miRNA也起到重要作用。一些心脏特异性miRNA表现出冠心病的诊断价值。中医药在冠心病治疗中发挥着重要作用,通过中医药与miRNA的研究发现,miRNA很有可能成为中医药理论发展的重要研究对象,成为证候标志物及中药研发的新靶点。本文对miRNA做一简单介绍,重点阐述了miRNA在冠心病中的作用,其作为冠心病生物标志物的潜力以及它与中医药的密切联系。

miRNA in Coronary Heart Disease and Traditional Chinese medicine

miRNA, as a 19~23 nucleotide non-coding RNA, plays an important role in biological growth, differentiation, cell proliferation and apoptosis. miRNA played an important role in pathologic remodeling process of coronary artery disease(CAD) and injury in myocardial contractility. Further research found that some cardiac-specific miRNA exhibited certain a diagnostic value of diagnoses about CAD, which was closely associated with traditional markers. Traditional Chinese medicine (TCM) played an important role in treating coronary heart disease(CHD). According to studies on TCM and miRNA,miRNA is likely to be a new target for the theory development of TCM theory, and syndrome remarker and development R&D of TCM. This paper gives a brief introduction of miRNA, and focuses on the role of miRNA as a potential biomarker for treating(CHD) and its close relationship with TCM.