交互式胸部18F-FDG PET与CT三维容积图像融合技术的建立

目的建立可在PC机上运行的交互式胸部^18F-脱氧葡萄糖(FDG)PET与CT三维容积图像融合显示技术。方法对8例肺癌患者进行^18F-FDG PET全身显像和胸部螺旋CT检查。将PET发射和透射扫描三维容积数据和螺旋CT断层图像数据传入PC机。通过CT断层图像三维重建、像素转换、数据转换，采用胸部PET透射扫描显示解剖信息，结合^18F-FDG图像显示的病灶，以及心脏、肝脏、肾脏、脊柱骨髓等生理性显像图进行定位配准。采用交互式方式，对沿X、Y、Z轴的水平偏移量和旋转偏移角度进行调整，实现胸部PET-CT三维容积图像融合。结果8例肺癌患者，^18F-FDG PET显像共发现胸部阳性病灶25处，通过交互式PET-CT三维容积图像融合，所有病灶均在CT图像上明确定位。结论该图像融合技术对胸部^18F-FDG阳性病灶定位诊断有一定价值。

Interactive 3-dimensional registration of stand-alone 18F-FDG whole-body PET with CT in the thorax

Objective To establish a method of 3-dimensional volume fusion of stand-alone 18F-fluorodeoxyglucose (FDG) PET with CT in the thorax. Methods 18F-FDG PET and CT studies were performed on 8 patients with lung cancer. CT raw data were reconstructed into three dimensional volume data. The mutual positioning of the volume data of PET and CT was repeatedly adjusted according to the inner marker of apparent anatomical structures and lesions until the accurate registrations were obtained. The registered PET study was then displayed on a hot metal scale overlaid on top of the gray scale CT study. Results All of the 25 lesions on 18F-FDG PET imaging in 8 patients were correctly located on CT images using the software of three dimension volumetric fusion of stand-alone 18F-FDG PET with CT in the thorax. The software can be run in a PC computer, and the whole computational performance time of the software algorithm is less than 10 min for one patient. Conclusion This technique can correctly locate the FDG uptake lesions in the thorax.