| 程序变湿变温药物稳定性试验 |
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| 引用本文： | 赵强,詹先成,李琳丽,李成容,林涛,尹小东,何宁. 程序变湿变温药物稳定性试验[J]. 药学学报, 2004, 39(12): 1001-1005 |
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| 作者姓名： | 赵强 詹先成 李琳丽 李成容 林涛 尹小东 何宁 |
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| 作者单位： | 四川大学,华西药学院,四川,成都,610041 |
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| 基金项目： | 国家自然科学基金资助项目(30171117) |
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| 摘 要： | 目的建立一种研究湿度对药物稳定性影响的简便实验方法。方法用程序变湿和程序变温加速试验方法,以青霉素钾为例进行药物稳定性试验。结果程序变湿和程序变温加速试验与恒温恒湿对照试验得到的青霉素钾的降解动力学参数基本一致。结论程序变湿变温加速试验可以应用于药物稳定性研究。
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| 关 键 词： | 药物稳定性 程序变湿变温加速试验 降解动力学 青霉素钾 |
| 收稿时间： | 2004-05-08 |
Effect of programmed humidification and temperature on drug stability |
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| ZHAO Qiang,ZHAN Xian-cheng,LI Lin-li,LI Cheng-rong,LIN Tao,YIN Xiao-dong,HE Ning. Effect of programmed humidification and temperature on drug stability[J]. Acta pharmaceutica Sinica, 2004, 39(12): 1001-1005 |
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| Authors: | ZHAO Qiang ZHAN Xian-cheng LI Lin-li LI Cheng-rong LIN Tao YIN Xiao-dong HE Ning |
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| Affiliation: | West China School of Pharmacy, Sichuan University, Chengdu 610041, China. |
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| Abstract: | Aim To simplify the study on the effect of relative humidity and temperature on drug stability. Methods The stability of penicillin potassium as a model was studied with programmed humidifying and heating. Results Results of our programmed humidifying and heating experiments are comparable to those of traditional experiment at constant humidity and temperature. Conclusion Programmed humidifying and heating experiments are applicable to drug stability study. |
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| Keywords: | drug stability programmed humidifying and heating experiments kinetics penicillin potassium |
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