| P物质和受体在纹状体边缘区内的分布及其与学习记忆功能的关系 |
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| 引用本文： | 包新民,舒斯云,包蓉,张魁华. P物质和受体在纹状体边缘区内的分布及其与学习记忆功能的关系[J]. 南方医科大学学报, 2002, 22(2): 102-106 |
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| 作者姓名： | 包新民 舒斯云 包蓉 张魁华 |
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| 作者单位： | 第一军医大学神经科学研究所,广东广州510282 |
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| 基金项目： | 国家自然科学基金(39770550)，广东省自然科学基金(950554) |
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| 摘 要： | 目的研究纹状体边缘区内的P物质和受体的分布特点及其与学习记忆功能的关系。方法用免疫组化、原位杂交方法研究纹状体边缘区内P物质及其受体的分布特点,再用受体基因封闭方法结合迷宫行为试验研究P物质受体与边缘区学习记忆功能的关系。结果纹状体边缘区内有大量的P物质免疫阳性纤维及受体蛋白和NK1mRNA的分布,封闭纹状体边缘区内的P物质受体基因后,大鼠的学习记忆能力显著下降。结论纹状体边缘区内的P物质和受体对纹状体边缘区的学习记忆功能有重要作用,推测这种作用是P物质通过其受体NK1调节边缘区中的5-HT等神经递质来实现的。
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| 关 键 词： | P物质 受体 神经激肽1 纹状体 边缘区 学习 记忆 |
| 文章编号： | 1000-2588(2002)02-0102-05 |
| 修稿时间： | 2001-10-10 |
Distribution of substance P and its receptor in the marginal division of rat striatum and its association with the function of learning and memory |
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| BAOXin-min,SHUSi-yun,BAORong,ZHANGKui-hua Instituteof Neuroscience,FirstMilitaryMedicalUniversity,Guangzhou,China. Distribution of substance P and its receptor in the marginal division of rat striatum and its association with the function of learning and memory[J]. Journal of Southern Medical University, 2002, 22(2): 102-106 |
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| Authors: | BAOXin-min SHUSi-yun BAORong ZHANGKui-hua Instituteof Neuroscience FirstMilitaryMedicalUniversity Guangzhou China |
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| Affiliation: | BAOXin-min,SHUSi-yun,BAORong,ZHANGKui-hua Instituteof Neuroscience,FirstMilitaryMedicalUniversity,Guangzhou510282,China |
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| Abstract: | Objective To investigatethedistributionof thesubstanceP(SP)anditsreceptorinthemarginaldivision(MrD)of ratstriatumandto understandtherelationshipbetweenSP andthelearningandmemoryfunctionof rats.Methods Using immunohistochemistryandin situ hybridizationtechniques,thedistributionof SP anditsreceptorintheMrDwasstudied,and therelationshipbetweentheSP andlearningandmemoryof theMrDwasobservedby meansof SP receptorgeneknockoutin combinationwithY-mazetest.Results NumerousSP immunopositivefibersandlargequantitiesof SP receptorproteinand NK1mRNAwereidentifiedin theMrDof ratstriatum.Afterknockoutof theSP receptorgenein theMrD,theabilityof learningandmemoryof theratswas obviouslydecreased.Conclusion SP anditsreceptorin theMrDmayplayimportant rolesin thelearningandmemoryfunctionof rat,possiblythroughtheregulationof theneurotransmittersas5-HTby SP via NK1receptor. |
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| Keywords: | substanceP receptors neurokinin-1 corpusstriatum marginaldivision learning memory |
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