| 白藜芦醇抗衰老免疫机制的研究 |
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| 引用本文： | 姚煜,田涛,南克俊. 白藜芦醇抗衰老免疫机制的研究[J]. 中药材, 2006, 29(5): 464-467 |
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| 作者姓名： | 姚煜 田涛 南克俊 |
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| 作者单位： | 西安交通大学第一医院肿瘤内科,陕西,西安,710061 |
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| 摘 要： | 目的:研究白藜芦醇抗衰老的免疫学机制,开发白藜芦醇新的临床用途。方法:建立小鼠衰老模型,然后用白藜芦醇干预,观察其对小鼠衰老现象的影响作用。结果:白藜芦醇干预组小鼠血清超氧化物歧化酶(SOD)含量升高,血清丙二醛(MDA)含量下降;该组胸腺指数升高而脾脏指数无明显改变;同时其血清中CD4 细胞数量不改变,而CD8 细胞数量升高,CD8 细胞与CD4 细胞比值降低;还能使血清中IL-6、IL-8的含量降低。结论:白藜芦醇具有一定的抗衰老作用。
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| 关 键 词： | 白藜芦醇 抗衰老 免疫 机制 |
| 文章编号： | 1001-4454(2006)05-0464-04 |
| 收稿时间： | 2005-09-25 |
| 修稿时间： | 2005-09-25 |
Research on Resveratrol''''s Mechanism of Immunity in Anti-aging |
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| YAO Yu,TIAN Tao,NAN Ke-jun. Research on Resveratrol''''s Mechanism of Immunity in Anti-aging[J]. Journal of Chinese medicinal materials, 2006, 29(5): 464-467 |
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| Authors: | YAO Yu TIAN Tao NAN Ke-jun |
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| Affiliation: | Internal Medicine of Oncology, Medical College, Xi'an Jiaotong University, China. |
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| Abstract: | Objective: To research resveratrol' s mechanism of immunity in anti-aging and explore the new clinical use of resveratrol. Methods: The sub acute aging model was made by continuous subcutaneous injection of D galactose to mice inducing reactive oxygen species ( ROS) . Meanwhile, the resveratrol was given and its effect on anti-aging was observed. Results: The resveratrol could in- crease the content of SOD and decrease the content of MDA in serum. There was no change in spleen index, but thymus index increased obvionsly. There was no change in the quantity of CD4 , but the quantity of CD8 increased and the ratio of CD4 /CD8 was decreased. The serum IL-6 and IL-8 level were decreased obviously. Conclusion: The resveratrol possessed the function to anti-aging and the applications foreground in anyi-aging. |
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| Keywords: | Resveratrol Anti-aging Immunity mechanism |
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