| 纳米抗体在肿瘤分子显像中的应用 |
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| 引用本文： | 周晓靓,王浩,刘鉴峰,孟爱民. 纳米抗体在肿瘤分子显像中的应用[J]. 中华核医学杂志, 2014, 0(6): 521-522 |
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| 作者姓名： | 周晓靓 王浩 刘鉴峰 孟爱民 |
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| 作者单位： | 中国医学科学院放射医学研究所、天津市分子核医学重点实验室,300192 |
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| 基金项目： | 国家自然科学基金（81171371） |
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| 摘 要： | 纳米抗体是一种由骆驼源的重链可变区组成的单域抗体，具有相对分子质量小、亲和力高和化学稳定性好等特性，非常适于进行肿瘤以及其他疾病的PET、SPECT显像和辅助治疗研究。纳米抗体在分子影像诊断方面的优势很可能使其成为新一代核医学显像剂。
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| 关 键 词： | 单域抗体 分子显像 肿瘤 发展趋势 |
Application of nanobodies in molecular imaging |
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| Zhou Xiaoliang,Wang Hao,Liu Jianfeng,Meng Aimin. Application of nanobodies in molecular imaging[J]. Chinese Journal of Nuclear Medicine, 2014, 0(6): 521-522 |
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| Authors: | Zhou Xiaoliang Wang Hao Liu Jianfeng Meng Aimin |
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| Affiliation: | . (Institute of Radiation Medicine, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin 300192, China) |
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| Abstract: | Nanobodies, which occur naturally in Camelidae animals, are the functional heavy chain antibodies without light chains. Having the relative properties of small size, high stability, good solubility and targeting effect, nanobodies have a great potential in PET and SPECT imaging for the diagnosis and treatment of diseases, such as tumor and infectious disease. Radio-labeled nanobodies might have potential to become the molecular imaging probes of the next generation. |
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| Keywords: | Single-domain antibodies Molecular imaging Neoplasms Trends |
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