非甾体类抗炎药与心血管事件风险的研究进展

非甾体类抗炎药是一类广泛用于消炎、镇痛的药物,根据对环氧化酶的选择性不同分为三类,研究发现其对心血管事件有一定的影响。环氧化酶-1选择性抑制剂对心血管疾病有二级预防作用,但一级预防作用尚存争议。大多环氧化酶-2选择性抑制剂增加心血管事件风险,部分尚存争议。非选择性抑制剂大多增加心血管事件风险,少部分则几乎无影响。现拟对非甾体类消炎药与心血管事件风险的研究进展做一综述。

Advances in Nonsteroidal Anti-inflammatory Drugs and Cardiovascular Events

Nonsteroidal anti-inflammatory drugs are widely used to diminish inflammation and pain. According to the ability to inhibit cyclooxygenase,they are divided into three categories. In recent years,lots of researches find that they have certain effect on cardiovascular events. Cyclooxygenase-1 selective inhibitors play a good role in the secondary prevention in subjects with cardiovascular disease,and are still controversial in primary prevention. Cyclooxygenase-2 selective inhibitors mostly increase the risk of cardiovascular events. Most kinds of non selective cyclooxygenase inhibitors also increase the risk. This view focuses on the research progress of the relationship of nonsteroidal anti-inflammatory drugs and cardiovascular events.