| 苦茶的化学成分 |
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| 引用本文： | 续洁琨,张维库,栗原博,姚新生.苦茶的化学成分[J].中国天然药物,2009(2):111-114. |
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| 作者姓名： | 续洁琨 张维库 栗原博 姚新生 |
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| 作者单位： | [1]北京中医药大学基础医学院,北京100029 [2]中国药科大学天然药物化学教研室,南京210009 [3]暨南大学中药及天然药物研究所,广州510632 [4]沈阳药科大学中药学院,沈阳110016 |
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| 基金项目： | The authors thank Prof. YE Chuang-Xin （Sun Yat-Sen University, Guangzhou, China） for identifying plant material. We are also grateful to Dr. LI Qian （Department of Phytochemistry, China Pharmaceutical University, Nanjing, China） and Dr. DAI Yi （College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China） for providing NMR and MS data. |
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| 摘 要： | 目的：对苦茶（Camellia assamica vat．kucha Chang et Wang）叶的化学成分进行研究。方法：采用水提取，聚酰胺、Sephadex LH-20、ODS柱和HPLC等手段分离纯化，通过理化常数和谱学数据鉴定化合物的结构。结果：分离鉴定了10个化合物，其中3个为嘌呤生物碱类化合物，分别为theacfine（1），caffeine（2），theobromine（3）；7个为茶多酚类，分别为（＋）-catechin（4），（-）-epigallocatechin（5），（-）-gallocatechin（6），（-）-epigaUocatechin 3-O—gallate（7），（-）-gallocatechin 3-O—gallate（8），1，2，6-tri—O—galloyl-β—D—glucose（9），gallicacid（10）。结论：化合物4-10为首次从该植物中分离得到，并首次对化合物1的核磁数据进行了全归属。
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| 关 键 词： | 苦茶 化学成分 嘌呤生物碱类 茶多酚类 |
Chemical Constituents from the Leaves of Camellia assamica var. kucha Chang et Wang |
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| XU Jie-Kun,ZHANG Wei-Ku,HIROSHI Kurihara,YAO Xin-Sheng.Chemical Constituents from the Leaves of Camellia assamica var. kucha Chang et Wang[J].Chinese JOurnal of Natural Medicines,2009(2):111-114. |
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| Authors: | XU Jie-Kun ZHANG Wei-Ku HIROSHI Kurihara YAO Xin-Sheng |
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| Institution: | 1School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029; 2Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009; 3Institute of Traditional Chinese Medicine ＆ Natural Products, Jinan University, Guangzhou 510632 4School of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China) |
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| Abstract: | AIM： To investigate the chemical constituents of the leaves of Camellia assamica vat. kucha Chang et Wang. METHODS： Chemical constituents were isolated by polyamide, Sephadex LH-20, ODS column and HPLC chromatography. The structures were elucidated on the basis of physiochemical characteristics and spectral data. RESULTS： Ten compounds were isolated and identified as theacrine （1）, caffeine （2）, theobromine （3）, （＋）-catechin （4）, （-）-epigallocatechin （5）, （-）-gallocatechin （6）, （-）-epigallocatechin 3-O-gallate （7）, （-）-gallocatechin 3-O-gallate （8）, 1, 2, 6-tri-O-galloyl-β-D-glucose （9）, and gallic acid （10）, respectively. CONCLUSION： Compounds 4-10 have been obtained from the plant for the first time and NMR data of I are firstly reported. |
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| Keywords: | Camellia assamica var kucha Chang et Wang Chemical constituents Purine alkaloids Tea polyphenols |
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